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Best Digestive Enzymes: Top-Rated Enzyme Supplements for Digestion

Digestive enzymes are supplements that help digest food easier, release nutrients and remove the toxic wastes from your body. The whole purpose of the digestive enzymes is to strengthen the endocrine system and disperse all the nutrients.

Also, balancing the cholesterol and triglyceride levels in your body, digestive enzymes aim at bettering many aspects of health.

These digestive supplements are highly efficient and recommended for people of all ages, young and old, healthy or sick – simply anyone. Such supplements comprise many ingredients to boost your immune system, support digestion, and even terminate other diseases.

However, given the extensive choice of digestive enzyme supplements, sometimes people face difficulties in what supplement to choose. Potential users often find themselves asking questions like which one is the best digestive enzyme, are there any side effects that might occur while using the supplement, and so on.

But, the most critical question is how to choose the best one?

For everyone who has trouble finding the best digestive enzyme for their taste, we are here to help you bring your doubts to an end. Keep reading to find out everything about our top-ranked supplements.

The Best Digestive Enzymes for 2021

We had to look upon many supplements based on the great selection and wide range of digestive enzymes. So, here is how we rated the top 18 digestive enzymes available on the market today:

  • 1MD EnzymeMD
  • EnzyBurn
  • Onnit DigesTech
  • BiOptimizers MassZYMES
  • Onnit Total Gut Health
  • BiOptimizers HCL Breakthrough
  • Live Conscious DigestWell
  • Organixx Enzyme 17
  • Vital Plan Active Enzymes
  • NSP Nutrition Digestive Enzymes
  • Natural Health Source Digestive Enzyme Renewal
  • Amy Myers MD Complete Enzymes
  • SynoGut
  • AlphaZym Plus
  • Gut Garden Digestive Enzymes
  • EnzyMedica Digest Gold
  • Thorne Bio Gest
  • VeganZyme

1MD EnzymeMD

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This digestive enzyme, created by board-certified Dr. David Kahana, can aid in the digestion of a wide range of meals. The EnzymeMD package contains 18 distinct enzymes, and each of them is useful for the digestion of some food types.

Also, some studies have shown that EnzymeMD efficiently helps with discomfort in your stomach and relieves the feeling of bloating and fullness after eating.

This digestive enzyme supplement is even more unique and special because, unlike some digestive supplements, it doesn’t use probiotics.

The EnzymeMD supplement consists of S.boulardii, perfect for abdominal discomfort and helps you get rid of the toxins and gases to lose weight.

After using this product, we assure you, you will see positive changes in your body after just a short period. This doctor-formulated and proven enzyme supplement comes at $43 for one bottle, which is a great and affordable price given all the benefits it will provide you.

Some reviews state that the product has a 4.9 out of 5, so we have declared it the best.


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Another top-quality digestive supplement, which is almost as good as our top-ranked, is EnzyBurn. This unique enzyme supplement was made thanks to a study about people who live on a specific exotic island and are skinny, healthy, and fulfilled.

According to the manufacturers, the island’s local population has found some beneficial enzymes that deliver visible results, benefiting the body, mood, and even the mental health of the residents.

The makers of EnzyBurn decided to use that enzyme to help people worldwide. Achieving outstanding results and lessening the discomfort in the abdominal areas, along with improving the mental sharpness, is what the supplement is all about.

Other benefits that have been seen from the usage of the EnzyBurn include improved skin appearance, optimistic and happy attitude, and proper digestion, among other pros.

You can get this enzyme supplement for $50 and enjoy its significant advantages. Also, this product is ideal for those of you who don’t want to exercise or be on strict diets but still lose weight and get your body into shape.

We are happy to say, none of the users of EnzyBurn have noticed any side effects, so don’t worry, the supplement is safe.

Onnit DigesTech

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Onnit DigesTech includes some of the best and most common enzymes today. It’s a complete package containing all the valuable enzymes you might need for any problem you have. These enzymes include amylase – for protein digestion, lipase – for carb digestion, and protease – for fat digestion.

The unique formula is different from other digestive enzyme supplements because it contains 14 powerful digestive ingredients.

Onnit DigesTech is perfect for those who are struggling with multiple digestion problems. The other aids contained in the formula include ginger extract, pepsin, serrapeptase and cellulase, flannel seed powder, and many more.

Also, this health-boosting and unique enzyme supplement comes at an attractive price of $32.95, which anyone can afford. Make sure you try this multifunctional supplement because you won’t regret it.

BiOptimizers MassZYMES

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MassZYMES is the name of the digestive enzyme supplement made by BiOptizimers, one of the best supplement companies nowadays. The company offers a wide range of enzyme supplements, but MassZYMES is the best among them.

MassZYMES offers a palette of different enzymes that are effective for digestion and optimal nutrient consumption.

This enzyme supplement can also increase your energy and improve your mental health, clarity, and focus, and of course, boost your metabolism and gut health. It comes in pills, which are supposed to be taken once a day for optimal results. However, we highly recommend taking one tablet in the mornings because it is proven that these enzyme supplements work better in the morning.

MassZYMES by BiOptimizers delivers the highest dosage among our best-ranked supplements. Each pill contains 100,000 units of digesting enzymes. Also, it’s the most expensive supplement due to the several valuable enzymes and high dosage it offers. It is priced at $75, which can be a little pricey for some people; however, keep in mind that it provides excellent benefits.

Onnit Total Gut Health

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Another Onnit product, which is undoubtedly as good as the first supplement we mentioned, is Onnit Total Gut Health. It has proved to be one of the best digestive enzyme supplements to support gut flora and improve digestion.

Many studies have recently shown that healthy gut flora is essential for many digestion problems, including issues with the weight loss process and enhancing your metabolism and overall health.

As a firm, Onnit has proven itself and all its products, especially highlighting Total Gut Health, which is of high quality and scientifically tested. Its proven and natural ingredients only add up to the recognition.

Since the Onnit Total Gut Health supplement costs $76 for 30 servings, it’s considered one of the most expensive digestive enzymes. The high price turns off some people, but you should try this supplement if you are experiencing some terrible digestion problems. After all, you can’t put a price on health, can you?

BiOptimizers HCL Breakthrough

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Another BiOptimizers digestive enzyme supplement is as good as the previous one. Because the same company made it as MassZYMES, it’s pretty similar and consists of similar enzymes and ingredients. HCL Breakthrough is a 100% natural and vegetarian product, safe to use by people of all ages.

This dietary supplement consists of enzymes enhancing B12 vitamins, minerals, and amino acid absorption. That means you can say goodbye to your stomach, gut problems, and digestion difficulties.

It’s preferable to drink one capsule a day to increase weight loss and improve metabolism. Some people even take this enzyme supplement to boost their muscle mass while exercising.

You can find the HCL Breakthrough supplement for $29, which is very affordable, contrary to MassZYMES, and start enjoying its benefits right away.

Live Conscious DigestWell

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Live Conscious DigestWell is another digestive supplement that uses a mix of digestive enzymes, plant-based enzymes, and probiotics for maximum results. The plant-based enzymes are proven to be safe and natural for use and have shown excellent results with digestion, bloating, and gases.

Some users have said that they have experienced visible improvements in their mood and energy after using this unique enzyme for only a short time.

This fantastic supplement consists of 10 fast and efficient enzymes and 100% natural ingredients such as ginger, papaya, and pineapple, which only contribute more to the weight loss process.

Live Conscious DigestWell is clinically proven and tested, making it safe for usage and one of the best options currently available on the market.

It’s also one of the most affordable supplements, priced at only $25 per bottle, and that’s why most people like it. Additionally, you are eligible for a 365-day cash back guarantee if you don’t like the supplement or don’t see any significant changes or visible results. It’s scarce to find this longspun, full money refund, so you better not miss this option.

Organixx Enzyme 17

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This amazing liver and pancreas enzyme supplement has gotten its name Organixx Enzyme 17 because of the 17 enzymes it uses. First, it’s crucial to spot warning signs of trouble and take action. If you start noticing some digestive problems, turn to this unique and efficient supplement boasting 17 different enzymes.

Organixx Enzyme 17 is one of the more high-dosage supplements on our list. It includes 3,000,000 FCCPU of bromelain, 22,500 DU of amylase, and 21 ENDO-PG of pectinase in its composition. These enzymes are beneficial and will ease your stomach pains and digestion problems.

The price for the digestive supplement is $50 per 30 servings. It is recommended that you take one dose a day; that’s why there are 30 servings meant for a one-month supply.

One of the other beneficial traits of this supplement is that Organixx Enzyme 17 was formulated by an apt and renowned medical specialist Dr. Melissa Gallagher. Dr. Gallagher states that the digestive enzyme supplement is essential for protein deficiency.

Vital Plan Active Enzymes

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Active Enzymes, manufactured by Vital Plan, delivers a mix of plant-based enzymes, around 15, to be precise, all of which help your body break down food.

For enhanced gastrointestinal comfort, the enzymes cardamom and fennel are included. We also appreciate Vital Plan’s Active Enzymes since it’s a doctor-formulated solution for better digestion.

Vital Plan Active Enzymes supplement packs a broad range of digestive enzymes to help with occasional gas, bloating, and irregularity in the stomach area. Some enzymes included in this supplement are protease, lipase, and bromelain.

Active Enzymes by Vital Plan will set you back for $33, backed by a 90-day money guarantee. So, don’t miss this great opportunity and don’t hesitate to purchase one of these supplements.

NSP Nutrition Digestive Enzymes

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Similar to the Organixx Enzyme 17, this one also boasts many enzymes that enhance protein digestion, among other perks. NSP Nutrition Digestive Enzymes have been proven to improve your sleep, energy and increase the fat-burning process. These advantages led to much better digestion and eased the weight loss process.

Another proudly claimed advantage is that NSP Digestive Enzymes include anti-aging nutrients. The supplement manufacturer states that some enzymes and ingredients in the formula can make your skin look fresher and younger while preventing lousy digestion.

Priced at $30, it falls into the group of the most affordable digestive enzyme supplements on our list. Additionally, the product offers a 30-day full money refund policy.

Natural Health Source Digestive Enzyme Renewal

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Another great supplement among the many is the Digestive Enzyme Renewal. Digestive Enzyme Renewal by Natural Health Source is a nutritional supplement that helps relieve gas, diarrhea, and constipation while reducing inflammation, reducing gastrointestinal pain, and increasing nutrient absorption.

So far, no side effects have been detected from using the product.

Digestive Enzyme Renewal is proven to be of use with chest burning, sore throat, burping, hiccups, stomach ache along with asthma, coughing, sleep difficulties, and other health problems.

Natural Health Source’s Digestive Enzyme Renewal is one of the best digestive enzyme blends on the market today, suitable for people fed up with the issues we mentioned earlier.

It’s priced around $50 per bottle, but considerable savings are available when ordering numerous bottles at once. Also, it comes with a 67-day full money amount refund.

Don’t miss the fantastic opportunity to save money while you equip yourself with a few bottles of this enzyme supplement.

Amy Myers MD Complete Enzymes

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Amy Myers MD Complete Enzymes is yet another digestive enzyme supplement that promotes proper digestion and nutrition absorption. You can assist the body in repairing intestines and responding to inflammation by taking Complete Enzymes daily, among other things.

Complete Enzymes was created by Dr. Amy Myers, a medical practitioner who understands the need for digestive enzymes. Dr. Myers highly recommends the product for anyone with food sensitivities, absorption or digestion disorders, gluten or lactose intolerance, or anyone who simply wishes to support healthy gut inflammation.

This fantastic enzyme supplement is one of the best-rated and most respected digestive enzyme supplements on the market today, costing $40 per bottle. Complete Enzymes outdoes expectations in several ways, including clear labeling and a 90-day money-back guarantee.


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A natural health specialist, Samuel Bart, produced SynoGut, a digestive enzyme supplement. Samuel designed the perfect digestive aid utilizing natural substances, and SynoGut is what he came up with.

This supplement contains many good and healthy ingredients and enzymes that are not found in most supplements on the market today.

Black walnut, oat, flaxseed, prune, aloe vera, lactobacillus acidophilus, apple pectin, and glucomannan are among the components found in SynoGut.

SynoGut also contains fiber, prebiotics, probiotics, and other nutrients that other digestive enzymes do not, which is sought after. The cost is a little higher than most digestive enzyme supplements on our list, which may throw some people off. However, once you try it, you will see how effective and worth the money.

AlphaZym Plus

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AlphaZym Plus, as a digestive enzyme supplement, specifically targets people who are looking to reduce weight. AlphaZym Plus is a weight-loss supplement with a money-back guarantee that tries to address the core reasons of obesity, such as intestinal imbalances.

So, if you are looking for ways to lose weight, keep in mind this unique product has an abundance of perks to offer.

AlphaZym Plus also contains ingredients like psyllium powder, slippery elm bark, aloe powder, acai berry fruit extract, inulin, and chlorella, in addition to digestive enzymes. Some of these nutrients help your body expel waste and toxins out of your body.

Others help to cleanse your system and help you get the results of looking leaner than ever.

Some people believe that good inflammation benefits weight loss and enhances digestion.

The price is $69, which might sound expensive at first, but when you consider all the great benefits you can get, it’s worth it. Plus, the digestive enzyme supplement uses proven and safe components and clinical concentrations to help you lose weight in various ways.

Gut Garden Digestive Enzymes

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Taking digestive enzymes daily can help to improve digestion, restore stomach acid, and relieve stomach pain. Digestive Enzymes utilize several mechanisms of action to support health and wellness in various ways, rather than merely feeding your system digestive enzymes.

As a more recent digestive enzyme supplement, Gut Garden does not currently hold the same level of recognition as some of the other top-rated firms on our list. But, despite this, people are already starting to comprehend the advantages that come with this product.

Digestive Enzymes, which costs roughly $25 per bottle, contain betaine, pepsin, bromelain, papain, and even ox bile extract to help with various health issues.

EnzyMedica Digest Gold

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EnzyMedica Digest Gold + Probiotics is a trendy digestive supplement that helps to speed up digestion, increase energy, and lessen occasional gas, bloating, and indigestion as per usual. A great advantage that draws customers to this digestive enzyme is the probiotic included in the formula.

Digest Gold is a multifunctional 2-in-1 digestive health supplement that uses popular and established digestive enzymes to break down fat, proteins, fiber, and carbohydrates. What makes it so specific is the formula that is also the only one on our list to include the unique TherActive probiotics, which enhance Digest Gold’s digestive effects even more.

It remains one of the top digestive enzyme solutions for anyone searching for overall complete digestive support, with 1.5 billion active cultures per serving and many proven components. Also, it comes at an affordable price of just $34.

Thorne Bio Gest

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With pepsin, pancreatin, and ox bile in their composition, the Bio Gest supplement can aid in the digestion of fats, proteins, and carbohydrates. All of these enzymes are required by your body to aid digestion. Your body has a more challenging time digesting foods as you become older or use more pills. Bio Gest is a perfect example of a supplement that can assist your health in many ways.

It’s also one of the few supplements you will find here that focuses on insufficient stomach acid output. Gallbladder removal, for example, causes some people to produce inadequate stomach acid. Thorne’s Bio Gest is a digestive enzyme supplement with a high-quality mix of ingredients that seeks to alleviate that problem.

As a top-rated digestive enzyme supplement, it costs very little, just $19 for 60 capsules, making it one of the most affordable.


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As its name says, VeganZyme is a digestive enzyme supplement strictly based on plant sources. Make sure you give your body the plant-based enzymes it deserves to promote optimal digestion, strengthen the immune system, and stimulate general wellness. Experience additional digestive advantages by taking VeganZyme daily.

The price is around $50 for a month’s supply. VeganZyme is also one of the few supplements on our list that comes with a full 365-day money-back guarantee. If you are dissatisfied with VeganZyme for any reason, you are entitled to a full money refund within one year after purchase.

What We Considered While Ranking Our Best Digestive Enzyme Supplements

Today, many diverse digestive enzyme supplements offer different ingredients and benefits. Also, every person has a different taste and different preferences about supplements.

However, what’s good is good. To help you decide between some of the best supplements, we have considered essential factors like manufacturer info, safety, licensing, ingredients and others.

So, here is detailed head-to-head criteria and the most important factors while choosing the best digestive enzyme supplements.

Proven Digestive Supplements

Maybe the most important thing when you purchase a digestive enzyme supplement is to see whether the product is proven or not. Remember that you will be feeding the supplement to your body, so make sure that it’s clinically proven and consists of natural and non-harmful enzymes and ingredients.

That is precisely why we only included proven supplements in our list and put these criteria at the top. Unproven enzymes and ingredients may cause some unwanted effects to appear.

Clinically Proven and Effective Dosages

In the realm of digestive enzyme supplements, dosages are varied. It’s not as straightforward as comparing specific dosages. Some enzymes have been shown to work in trials while other dosages have not. When ranking the best enzyme supplements, we looked for those that employed effective, clinically-effective dosages of numerous established and safe enzymes.


Digestive enzymes are only effective if they reach your gastrointestinal tract. The enteric coating on best-rated digestive enzyme supplements helps them withstand stomach acid and ease the difficulties. The more extended digestive enzymes are active, the more visible the results. That’s why, even though some digestive enzyme supplements had equal doses, one ranked higher than the other.

Advertised Benefits

Digestive enzyme pills will not help you lose a lot of weight in a week or prevent diabetes or other life-threatening diseases. However, digestive enzymes are a critical component of a balanced but healthy diet and lifestyle.

We were skeptical of digestive enzyme supplements that made claims too good to be true. The touted benefit of good digestive enzyme supplements was open and honest.

Price and Additional Costs

People are willing to pay differently for a digestive enzyme supplement. You can determine how much you can spend on your perfect supplement based on your budget.

Some supplement prices vary between $10 and $200 per bottle. However, we chose digestive enzymes that everyone can afford on our list.

However, keep in mind that sometimes higher costs mean higher quality, so it would be good to spend a little more on a good, quality supplement if you can afford it financially.

Number of Digestive Enzymes

Another important trait is the number of enzymes contained in the digestive supplement. Usually, the optimal range is for the supplement to consist of 10 to 15 digestive enzymes. Some enzymes break down proteins, and some break down carbs, so it’s always suitable for a supplement to have more ingredients and enzymes in its composition.

It’s recommended that less or more than the average amount be avoided.

Doctor Formulated

For safety reasons, you should always choose a digestive supplement made by a licensed and certified doctor or another kind of medical professional. For that reason, we have selected only the best doctor-formulated enzyme supplements for you.

It’s always better to be safe than sorry. For example, our top-rated EnzymeMD formula has been created by a board-certified gastroenterologist. That’s always a good sign to look for when you buy digest enzymes.

More Manufacturer Info

Another essential trait is the manufacturer’s history, quality, and ranking. Some supplement producers have a track record of producing high-quality supplements. But, other companies are relatively new and untested. Some manufacturers use third-party lab testing, while others simply trust their product is as pure as it claims. We looked at the manufacturer’s reputation and transparency in determining our rankings.

Money-Back Guarantees and Refunds

If you have issues with the digestive enzyme supplement or don’t see any visible results after using them for quite some time, we are happy to tell you many of our best-ranked supplements offer cash-back guarantees.

Sometimes, you won’t tell if digestive enzyme pills are functioning. If your digestive enzyme supplement did not provide any benefits, or if you were disappointed with your purchase for any reason, you are eligible for a refund.

We chose digestive enzyme supplement suppliers who offered a money-back refund on their products.

Ingredients Used in the Formula

Probiotics, prebiotics, and other digestion-supporting substances are included in several of our best-ranked digestive enzyme supplements. We primarily evaluated digestive enzyme supplements based on their digestive enzyme content.

In our listings, however, we also considered the additional factors. Plus, we ensured that all ingredients used in the formula were 100% natural and efficient.

What Are Digestive Enzymes?

Digestive enzymes, scientifically speaking, are substances produced by the body to aid in the digestion of meals. As food passes through your gastrointestinal (GI) tract, your body lets go of the digesting enzymes.

The digestive enzymes also break down the foods you ingest into your body, extract valuable nutrients, and guarantee that the nutrients go where they’re supposed to go.

It’s been proven that digestive enzymes deliver many other benefits and advantages and are not limited to just the digestion of food and keeping the nutrients within your body. Some of those advantages include improving your metabolism and gut function, enhancing your mood and giving you a feeling of relaxation, increasing protein levels, and many others perks.

What Are Digestive Enzyme Supplements?

Digestive enzyme supplements are products made to improve your digestive system while helping you lose weight. Supplements often come in capsules or powders and are usually intended daily.

Some people are on a well-balanced diet, and their systems create digestive enzymes regularly to aid in the digestion of the foods they consume. Others, unfortunately, deal with digestive enzymes that are out of track.

When you quit consuming a particular food group, your body stops producing digestive enzymes for that specific food. That’s why some people have trouble digesting dairy, meat, or other high-protein diets. Your body no longer utilizes the digestive enzymes it formerly did to aid in digesting the food you eat.

If your digestive enzymes are out of balance or you experience digestive problems frequently, you should consider taking a digestive enzyme supplement.

However, supplements can be taken for losing weight or for health reasons if you are dealing with some abdominal disease.

How Does the Process of Digesting Food Work?

The digestive process is individual, and several factors depend on how food passes from the mouth into the esophagus, stomach, intestines, and out of the body.

The digestive process depends on the characteristics of the food, its chemical composition, gastric pH, and intensity of peristalsis.

When we talk about digesting food, we don’t realize there is a whole process.

It begins when you intake the food into your mouth and chew it, and that’s also called the mechanical part of digestion.

Your body breaks down food with chemicals and other components at the molecular level, converting large molecules into smaller ones.

When these two processes work together, the nutrients you eat are released. After that, as food passes through the GI system, it comes into contact with digestive enzymes. Various digestive enzymes continue to break down the meals you have, allowing nutrients to be absorbed along the way.

Possible Signs of Low Digestive Enzyme Counts

If your digestive enzyme count is low, you may find it challenging to process the meals you eat. Here are some of the signs that point to it:

  • Loose stool or confinement
  • Weight gain or weight loss that isn’t expected
  • Stomachache
  • Visible particles of undigested food in the stool
  • A feeling of bloatedness and presence of gas

Due to insufficient digestive enzyme numbers, you may experience malnutrition symptoms in some situations. You can’t get nutritional value from meals since your body can’t use digestive enzymes to break down what you eat.

Best Foods For Digestive Enzymes

Digestive enzymes are in short supply in certain foods. Although these meals can help supplement your body’s natural digestive enzymes, they are unlikely to change your GI health completely. The following foods and the digestive enzymes they contain are some of the best sources of digestive enzymes:

  • Bananas
  • Pineapples
  • Papaya
  • Avocado
  • Kefir, kimchi, sauerkraut

How Digestive Enzyme Doses Work

For those who have looked at a digestive enzyme label and probably have been perplexed by the dosages, here we simplify what they mean. The Food Chemical Codex (FCC) provided these figures. It’s a compilation of food-related metrics.

The following are some of the most digestive enzyme measures used in the FCC:

  • Amylase: DU
  • Protease: HUT, PC, SAPU
  • Lipase: LACU, ALU
  • Lactase: LU, FIP

Some digestive enzyme firms take advantage of these acronyms by inventing new digestive enzyme dosages and embellishing them with attractive numbers and letters. For example, you might encounter a supplement called Amylase 1,500 FCC.

Which Digestive Enzyme Supplement Should I Choose

When looking for digestive enzyme supplements, you’ll notice that certain strains come up repeatedly. Digestive enzymes are divided into three categories, and they are:

  • Protease, bromelain, papain, and nattokinase, are all protein targeting enzymes
  • Lipase, which is a fat targeting enzyme
  • Amylase, lactase, cellulase, and alpha-galactosidase, which are carb targeting enzymes

Most Common Digestive Enzymes

The following are some of the most prevalent digestive enzymes, as well as the meals that they target:

  • Lipase is an enzyme that breaks down fats and oils.
  • Protease breaks down proteins.
  • Alpha Galactosidase is a starch enzyme found in legumes.
  • Peptidase is an enzyme that breaks down specific proteins, such as gluten and casein.
  • Amylase is an enzyme that breaks down starches.
  • Pectinase is a pectinase enzyme that breaks down pectin in fruits.
  • Invertase breaks down sucrose sugar.
  • Lactase is a sugar found in dairy products.
  • Glucoamylase breaks down maltose sugar.

10 Best Benefits and Advantages of Digestive Enzymes

So far, we have concluded that digestive enzyme supplements may be helpful for various reasons. For example, some people use digestive enzyme supplements to help with malnutrition, and others utilize them because of protein absorption. Stay tuned to read about the best ten advantages these enzymes deliver.

Absorbing Proteins

Protein absorption is a primary goal for many digestive enzyme supplements. You might take a digestive enzyme supplement if you wish to increase your protein intake to combat protein gas and bloating.

Bloating and Gas

If you often find yourself while experiencing difficulties with gas and bloating as a reaction to certain foods, it’s time you try some digestive supplements. This condition usually occurs after eating carbs, proteins, or unhealthy food.

Improving Nutrient Absorption

For those chronically suffering from malabsorption, it can be caused by several factors. Whether the purpose is enzyme struggles or bad diets, either way, the answer is to use digestive enzyme supplements.

Targeting Specific Diseases

For example, in the pancreas, your body generates digesting enzymes. If you have a pancreas condition, you should consider taking a digestive enzyme supplement. Or, if you have another condition, consult a doctor.


Digestive enzymes may also help if you suffer from this IBS, i.e., irritable bowel syndrome. Many people who combat IBS symptoms take supplements before eating to ease the pain and discomfort in the stomach.

Lactose Intolerance

Lactose-intolerant people may benefit from digestive enzyme supplements. Lactose intolerance can be caused by a lack of lactase, a digestive enzyme that breaks down the lactose protein in milk.


Hypochlorhydria is a condition caused by too much stomach acid. Minerals, vitamins, and nutrients are challenging to digest with this condition. To help with hypochlorhydria, some people use a digestive enzyme supplement.

Age-related Enzyme Deficiency

Your stomach grows more alkaline as you get older. It may be more challenging to release digestive enzymes due to this. To combat age-related enzyme insufficiency, many people use digestive enzyme supplements.

Liver Issues

An enzyme deficiency is common in people with liver illness. Enzyme malfunction is also associated with Crohn’s disease, iron deficiency, vitamin B12 deficiency, and vitamin D deficiency.

ALSO READ:Best Liver Health Supplements – Review Top Liver Detox Pills

Optimize the Imbalanced Diet

Bloating, gas, indigestion, and other digestive problems may occur if your diet is unbalanced or unpredictable. Some people use a digestive enzyme supplement to help sustain an irregular diet, such as frequently traveling, working shifts, or eating at odd hours.

What Does Science Say About Digestive Enzymes?

One of the best and most comprehensive studies about digestive enzymes was released in 2016. Due to breakthroughs in digestive enzyme research, the researchers discovered that a mix of various enzymes could offer an exciting treatment alternative in the future.

Later, researchers tested the safety and efficacy of a digestive enzyme supplement which consisted of many enzymes, according to this 2018 study. After 40 people were given enzymes, researchers discovered that the digestive enzyme showed statistically significant improvements in the occurrence of indigestion symptoms after 60 days of supplementation.

Based on a study by Mayo Clinic, digestive enzymes show anti-inflammatory and anti-cancer features along the digestion process. This fantastic study backs that fact up.

Another Harward study also agrees that digestive enzyme supplements have a lot of benefits to offer. Despite all the info, insufficient evidence supports their usage for specific disorders such as heartburn needs further research.

1MD, the maker of the best digestive enzyme supplements, states that studies reveal many benefits associated with digestive enzyme supplements, including improved digestion, less fat in feces, and other beneficial digestive effects.

FAQs About Digestive Enzymes

We get a lot of inquiries about the way digestive enzymes work. To answer most of the frequently asked questions, we’ve made a list of Qs and As, and hopefully, you’ll get all the good info.

Q: When is the ideal time to take digestive supplements?

A: It’s recommended that you take digestive supplements once a day, around 15 to 30 minutes before you eat. Some studies prove that taking the supplement in the morning and specifically before eating shows more considerable improvements.

Q: How do I consume digestive enzyme supplements?

A: Most often, the supplements are in the form of a pill or powder. You drink one capsule a day before you eat, and if it’s a powder, you mix it with a drink, preferably water, for better results.

Q: Are digestive enzyme supplements helpful with lactose intolerance?

A: Yes, some studies have shown that digestive enzyme supplements do indeed help with lactose intolerance. Lactose intolerance can be triggered when your lactase enzyme doesn’t work well and leads to some abdominal problems and digestion difficulties. To improve digestion, using supplements is highly recommended and valuable.

Q: What are digestive enzymes?

A: Digestive enzymes are natural compositions in your body that break down the food you consume. They help with the weight loss process, making it more straightforward while delivering other benefits such as improving the digestive tract and abdominal function.

Q: How long does it take for the enzyme supplement to work?

A: Usually, the digestive enzyme supplement starts working around 45 minutes to 1 hour after ingesting it.

Q: What is the purpose and effect of digestive supplements?

A: Digestive enzyme supplement’s primary purpose is to reduce digestive discomfort and gut pain, all the while giving you a feeling of relief. Additionally, they improve your metabolism and boost your body’s vitamin and mineral levels.

Q: Are digestive enzymes helpful with cystic fibrosis?

A: Yes, based on the review of the Cystic Fibrosis Foundation, a significant percentage of people who suffer from cystic fibrosis take these supplements. However, you shouldn’t take just any kind of digestive supplement before talking to a doctor or a medical specialist to determine which enzymes you should take.

Q: Where does my body produce the digestive enzymes?

A: Digestive enzymes are produced mainly in the gastrointestinal tract and pancreas. But, that includes your mouth, stomach, and intestines, as well.

Q: How are digestive enzyme supplements able to help me?

A: Digestive enzyme supplements can be helpful with a variety of digestive issues, including:

  • Relieve bloating and gas while providing you a feeling of relief
  • Assist digestion by avoiding partly digested food from irritating your intestines
  • Promoting a healthy environment and easing gut functions

Q: Where do digestive enzymes come from?

A: Nowadays, digestive enzymes mainly come from plants. Digestive enzyme supplements came from the cow and pig pancreas or abdomen in the past. However, today the digestive enzymes come strictly from plant-based vegetarian sources.

Q: What’s the best ranked digestive enzyme supplement?

A: As you previously read, all supplements on our list are considered the best. But, our number 1 enzyme supplement is the EnzymeMD. However, everyone has different tastes and preferences, so the best product is different for every user.

Q: How does the process of digesting food work?

A: Digestion is the process of breaking down the food you have consumed. The mechanical part is where you eat the food with your teeth through your mouth, and after that comes the chemical part when the enzymes start their work.

Q: Which digestive enzyme should I use?

A: Many types of enzymes are used in digestive supplements. Some of them that are most popular and well known include lipase, protease, and amylase.

Q: Can anything happen when the food is not partially digested?

A: Yes, unfortunately, if you can’t digest the food you consume, some problems might occur. You can get some stomach irritations and indigestion, along with slowing down the metabolism and experiencing gut difficulties.

Q: Which kinds of food are the best sources of enzymes?

A: The best foods packed with enzymes are vegetables, fruits, nuts, and raw meats. But, you can’t get the same amount of enzymes from food as you get from digestive supplements.

Q: What is the meaning of protease?

A: Protease is a type of digestive enzyme which breaks down proteins. The proteins also help with throwing out the bacteria and parasites. In addition, the protease can give you a feeling of relief in your stomach.

Q: What does amylase mean?

A: An amylase is an enzyme that targets carbohydrates and is often used to decrease blood sugar levels. Amylase is present in the mouth and saliva and helps with food digestion.

Q: What does lipase mean?

A: Lipase is yet another enzyme produced by the pancreas and helps digest food. It can be constructive to decrease your cholesterol levels.

Q: Which is a better choice: plant-based or animal-sourced enzymes?

A: Both enzymes are suitable and have been clinically proven useful. However, most people prefer plant-based vegetarian enzymes because they possess different pH environments and are more common. The animal-based enzymes come from the stomachs of pigs and cows and have a pH from 8.0 to 9.0.

Q: Which foods contain the most digestive enzymes?

A: Many foods have enzymes, but the ones with the most include pineapple, papaya, honey, banana, avocado, mango, etc.

Q: What is the cause of low digestive enzymes?

A: There are several reasons why you can have low digestive enzymes, and they are:

  • Not enough exercise
  • Wrong and unbalanced diet plan
  • Too much food consumption
  • Unhealthy food
  • Too much exercise
  • Some medical problems and conditions

Q: Are digestive enzyme supplements beneficial?

A: A recent review from 2016 has shown that modern digestive enzyme supplements may offer an attractive therapeutic alternative soon. While some studies suggest that digestive enzymes aren’t helpful and efficient, people who have used them have said otherwise.

Q: Are digestive enzyme supplements safe for use?

A: Yes, it has been proven by many studies that these enzyme supplements are safe for you and your body. There are many reviews that you can find where satisfied customers tell their experiences. However, consult with a medical professional before taking enzyme supplements.

Q: Who should take digestive enzymes?

A: There are many reasons why people take digestive enzymes. It’s recommended that people who suffer from abdominal irritation and discomfort, have chronic pains, pancreatic or gut disease, and use these enzymes. But, some people simply use supplements to support their GI health.

Q: Are there any side effects of digestive supplements?

A: Side effects could occur but are rare and not likely to happen. Some people may experience unwanted effects such as constipation, diarrhea, headaches, nausea, but it doesn’t mean that everyone will end up experiencing side effects.

Q: What is the best digestive enzyme for people who struggle with gluten intolerance?

A: An enzyme called glutenase is probably the best choice for gluten problems. As you all know, gluten is a protein, and the glutenase is not an actual enzyme. It can be peptidase, protease, or some other digestive enzymes.

Q: How long does it take to see significant results from using digestive enzyme supplements?

A: The enzyme will likely start working between 20 and 30 minutes after ingestion. They help you break down the food you have ingested before taking the supplement. Also, body-wise, you can notice visible results only after a month of using enzyme supplements; however, the time range is different for everyone.

Q: Is a raw food diet good for digestive enzymes?

A: This depends. Raw food can offer some efficient digestive enzymes. But, the supplements contain different types of digestive enzymes.

The Best Digestive Enzymes for 2021 Final Words

The quality of the digestive enzyme supplements is paramount when choosing a supplement. Nowadays, the percentage and amount of different enzyme supplements are considerable. You can find a wide range of enzyme supplements on the market, however, make sure they are the perfect ones for you.

We hope that we have helped you decide which digestive supplement is the best and ideal choice for you. You can confidently choose your supplement based on our criteria of the best digestive enzymes reviews.

We have everything for you, whether you have specific conditions such as lactose intolerance, abdominal difficulties, cystic fibrosis, or want to improve your metabolism and lose weight.

Look at our list above for those who want to read more about the best digestive enzymes and think they need additional information.

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