Best Nootropics (2021) Top 30 Nootropic Supplements to Review

Whether you’re a student hoping to get good grades, an entrepreneur trying to maximize your profits, an employee seeking a promotion, or an older adult fretting about dementia, you can take brain-boosting supplements to enhance your cognitive performance. Irrespective of what age group you belong to, nootropic supplements can improve your brain performance by boosting mental functions, i.e., memory, motivation, attention, creativity, etc.

Though the most recommended way to improve cognitive performance is to make healthy lifestyle choices, i.e., adequate sleep, regular exercise, healthy diet, and stress management, nootropics add to healthy lifestyle choices.

What Are Nootropics?

Nootropics, aka “smart drugs” or “cognitive-enhancers,” help enhance brain power and cognitive functions, i.e., memory, motivation, creativity, and executive functions, e.g., planning, organization, time management, self-control, self-monitoring, working memory, and adaptable thinking.

Though nootropic supplements help boost brain performance, they are not meant to treat cognitive disorders, like:

  • Dementia
  • Alzheimer’s Disease
  • Motor Skill Disorder (Dyspraxia)
  • Behavioral Disorders
  • Attention Deficit Hyperactivity Disorder (ADHD)
  • Neurological conditions like Narcolepsy (impaired ability to regulate sleep-wake cycles)

The Top 33 Nootropic Brain Booster Supplements

With zillions of over-the-counter nootropic supplements available in the market, picking an effective and safe supplement to support your brain health is not going to be a cinch for you. Therefore, our editorial team has prepared a list of the safest and most effective nootropic supplements available in the market whose effectiveness in boosting brain power has been corroborated by ample scientific research and anecdotal evidence. The enumeration of the products in the list is not relevant to their quality or effectiveness.

  • Mind Lab Pro
  • Brain C-13
  • Memo Defend
  • MemoSurge
  • Nootrogen
  • PureHealth Research Ageless Brain
  • Organixx Ageless Brain
  • SANE Vitaae
  • Onnit Alpha Brain
  • Brain Boost
  • Performance Lab Mind
  • Nuzena Neuro Focus +
  • NooBru
  • Hunter Focus
  • BrainPill
  • OptiMind
  • Youthful Brain
  • Mind & Mood
  • BrainEssence
  • Elm & Rye Nootropics
  • Memory HackCymbiotika Golden Mind
  • Amy Myers MD NeuroLive
  • ReMind Solution
  • Oweli Neuro
  • ProMind Complex
  • NeuroGum
  • Qualia Mind
  • NeuroActiv6Synapse XT
  • NooCube Brain Productivity
  • NeuroFuel
  • CogniBiotics

Here are the top 33 brain-boosting supplements available in the market:

Mind Lab Pro


Mind Lab Pro is infused with 11 well-researched and clinically tested brain-boosting ingredients, one of the most famous nootropic formulas. It also contains several patented and advanced nutrients, including NutriGenesis®, a blend of vitamins, minerals, and amino acids created by seeding live single-cell organisms with micronutrients in a hydroponic system. The patented blend also contains a matrix of cofactors such as:

  • Mannan
  • Beta-1
  • 3-glucans
  • GPx4 (glutathione)
  • Superoxide Dismutase
  • Digestive-supportive Prebiotics
  • Probiotics
  • Citicoline
  • Lion’s Mane Mushroom
  • Rhodiola Rosea extract
  • Phosphatidylserine
  • Bacopa monnieri

NutriGenesis® aids in the absorption of other nutrients present in the nootropic formula by boosting their bioavailability.

Priced at $69, Mind Lab Pro is a bit expensive compared to most supplements on the list. Nonetheless, the potent formula of Mind Lab Pro is worth the price. It has no pointless or filler ingredients and is rated as one of the best nootropic formulas on the internet. It is a perfect introductory nootropic for people who are taking a brain-boosting supplement for the first time.

Mind Lab Pro was developed by Opti-Nutra, a health and wellness company led by competent neuroscientists. Dr. Ramon Velazquex Ph.D. serves as the head of the medical advisory board of the company.

Brain C-13


Developed by Zenith Labs, Brain C-13 is a brain-boosting nutritional supplement replete with essential minerals, vitamins, and plant and herbal extracts that synergistically inhibit age-related cognitive decline and improve brain performance. The supplement contains:

  • Dimethylethanolamine (DMAE)
  • Rhodiola root extract
  • Turmeric
  • Huperzine A
  • Phosphatidylserine
  • Mucuna pruriens
  • Rosemary leaf
  • Centella Asiatica
  • Sarcosine
  • Acetyl-l-carnitine
  • Magnesium l-threonate
  • Vinpocetine
  • CDP-choline

The formula of Brain C-13 is designed under the supervision of Dr. Ryan Shelton, medical research director at Zenith Labs. Brain C-13 boosts your cognition by inhibiting age-related or abnormal changes in the chemical composition of your brain, thereby mitigating the chances of cognitive decline. The supplement is highly beneficial for people above 40 years of age. It is manufactured in an FDA-regulated GMP-certified facility and is one of the safest products on the list.

Memo Defend


Developed by a researcher named Thomas Taylor, Memo Defend is a nutritional supplement that supports your cognitive health by reversing memory loss. Marketed to older adults, the supplement boosts brain function to inhibit the symptoms of age-related cognitive decline, e.g., memory loss.

Memo Defend claims to eliminate degenerative brain conditions, improve memory recall, and support cognition, infused with high-powered natural ingredients. The supplement contains healthful ingredients like:

  • Green tea
  • Juniper
  • Hibiscus
  • Hawthorn
  • Garlic
  • Olive
  • Buchu
  • Vitamin C
  • Niacin

The formula contains optimal dosages of all ingredients with 620 milligrams of its proprietary blend per serving.

Though the brain-boosting properties of the elements present in Memo Defend are not supported by ample scientific evidence, anecdotal evidence suggests that Memo Defend delivers good results. One bottle of Memo Defend is priced at $69.



MemoSurge is another memory loss supplement that claims to repair nerve damage to reverse age-related cognitive impairment. The supplement is packed with highly potent ingredients like phosphatidylserine, n-acetyl-l-carnitine, bacopa monnieri extract, and St John’s wort. The formula purportedly boosts your brain function in three steps, i.e., it strengthens neurotransmitters in your brain, nourishes and rejuvenates brain cells, and prevents brain shrinkage.

MemoSurge helps you regain old memories by repairing brain cell damage that is known to cause memory impairment. The formula helps eliminate mental problems like anxiety and insomnia, boosts your energy levels, and improves your attention and focus. MemoSurge comes with a few downsides like undisclosed ingredients and limited information to support the claims made by the manufacturer.



Infused with 30 mind-boosting ingredients, Nootrogen helps support brain wellness while alleviating stress and anxiety. The supplement helps relieve symptoms of mild cognitive impairment, e.g., short-term memory loss and dementia. It enhances your brain performance by retaining neural pathways, restoring degenerative brain cells, and improving nerve signaling in the brain.

Nootrogen contains a potent blend of brain-boosting ingredients:

  • Bacopa extract
  • Glutamic acid
  • Phosphatidylserine
  • Dimethylethanolamine (DMAE)
  • L-tyrosine
  • Magnesium
  • Vitamin B6
  • Vitamin B5
  • Vitamin B3

It also includes a 642mg proprietary formula.

Priced at $30 per bottle, Nootrogen is one of the most reasonable supplements on the list. It has the edge over other supplements on the list due to its price-to-value ratio and premium quality standards. Nootrogen is manufactured in compliance with Good Manufacturing Practices in an FDA-registered facility and undergoes rigorous clinical testing making it one of the safest products on the list.

PureHealth Research Ageless Brain


Developed by PureHealth Research, Ageless Brain is a cognitive-enhancement supplement that helps you reclaim your memory capacity. Packed with powerful mind-boosting ingredients, the supplement boosts your energy levels and heightens your brain’s ability to focus. The key elements present in Ageless Brain include gamma-aminobutyric acid (GABA), caffeine anhydrous, niacin, bacopa extract, alpha glycerylphosphorylcholine, l-theanine, green tea extract, huperzine-A, l-tyrosine, phosphatidylserine, and a 600mg proprietary formula. The company does not disclose the exact dosage of each ingredient.

Ageless Brain is formulated to boost neuromodulators, e.g., acetylcholine improves your intelligence level by enhancing your brain’s ability to concentrate. It also promotes healthy blood circulation in the brain to improve brain function and prevent brain shrinkage and age-related cognitive declines. Ageless Brain costs $44 per bottle and comes with a one-year money-back guarantee.

Organixx Ageless Brain


We have two supplements on the list that are named “Ageless Brain.” The Ageless Brain nootropic supplement developed by Organixx is a bit pricey and costs $55 per bottle. The supplement contains brain-boosting organic ingredients sourced from Amazon Rainforest, e.g., dragon’s blood, camu camu, cacao, cinnamon, guayusa, and bacopa monnieri that help supercharge your memory and improve brain function.

Manufactured in a cGMP facility, Ageless Brain by Organixx claims to reduce symptoms of cognitive impairment. The supplement is formulated to support cognitive health in many ways, i.e., eliminates brain fog, helps maintain mental clarity, improves mental focus, and promotes calm feelings. Infused with antioxidants, the formula present in Ageless Brain prevents oxidative cell damage in the brain, alleviates inflammation in the nervous tissue, and promotes undisrupted communication between neurons.

SANE Vitaae


Developed by SANE, Vitaae is an anti-aging formula infused with essential vitamins and herbal extracts that boost brain function by reducing inflammation in brain tissue and reversing damage caused by free radicals. The supplement contains eight potent ingredients that work synergistically to improve memory, learning, focus, and other aspects of your cognitive health.

In older adults, Vitaae helps minimize age-related cognitive decline by preventing mental slips from progressing. In addition to improving brain function, Vitaae boosts your immune response to prevent your brain cells from future damage.

The key ingredients present in Viatee include vitamin D, folate, citicoline sodium, coenzyme Q-10, and a 160mg proprietary blend called VitaalMind. All ingredients present in Vitaae are safe, well-researched, and clinically studied. Priced at $47 per bottle, Vitaae comes with a one-year money-back guarantee.

Onnit Alpha Brain


Developed by Onnit, Alpha Brain is a dietary supplement that helps support memory, focus mental speed, and other aspects of your cognitive health. It is one of the most popular nootropic supplements available in the market. Alpha Brain helps you achieve mental clarity so that your brain responds to stimuli and processes things efficiently. The supplement is caffeine-free, nut-free, dairy-free, and gluten-free, which arguably makes it the best nootropic supplement sold online.

Alpha Brain contains natural cognitive-enhancers like bacopa monnieri, oat straw, Huperzia Serrata, and Cat’s Claw. The supplement also contains proprietary blends with disclosed individual doses of most ingredients. Priced at approximately $27 per bottle, Alpha Brain is one of the most budget-friendly supplements on the list.

Brain Boost


Developed by Vital Plan, Brain Boost is a nootropic supplement that boosts your cognition to support memory, mental clarity, focus, and your brain’s processing speed. Additionally, it helps improve immunity, boost energy levels, and alleviate physical and psychological stress. The primary ingredients present in Brain Boost include Ginkgo Biloba, cat’s claw, lion’s mane mushroom, and bacopa monnieri. These ingredients help improve brain function while supporting other aspects of your overall body health, e.g., digestion. Some of these ingredients possess metabolism-boosting properties that promote healthy gut flora to enhance digestion and prevent gastrointestinal problems.

Designed by Dr. Bills Rawls, MD, Brain Boost contains no proprietary formulas and costs $48 per bottle. The supplement has transparent labeling with dosages of all ingredients disclosed, due to which it is deemed one of the best nootropic supplements of 2021.

Performance Lab Mind


As the name suggests, Mind is an effective mind-boosting formula developed by Performance Lab. The supplement purportedly boosts your brain energy up to 13.6%. Additionally, it helps alleviate symptoms associated with brain fog, i.e., confusion, poor concentration, lack of mental clarity, inability to focus, forgetfulness, low motivation, low energy, sleeping difficulties, and headaches.

Mind contains potent brain-boosting ingredients like:

  • Phosphatidylserine
  • L-tyrosine
  • Citicoline
  • Maritime pine bark extract

These ingredients eliminate mental fatigue and help you recover from intense cognitive exertion. Priced at $69 per bottle, Mind contains powerful antioxidants, vitamins, and minerals required by your brain to function correctly.

Nuzena Neuro Focus +


Developed by Nuzena, Neuro Focus + is a nootropic supplement that promotes optimal brain function. The supplement improves your brain performance by supporting your mental focus, memory recall, and cognitive function.

Neuro Focus + alleviates many types of cognitive dysfunction symptoms, e.g., mental fatigue or brain fog. Infused with potent antioxidants, the supplement repairs brain damage caused by free radicals. It dilates the arteries and veins present in the brain to increase blood circulation, thereby improving your brain’s uptake of oxygen and nutrients.

Neuro Focus + contains a 692mg proprietary blend with active ingredients like:

  • Glutamic acid
  • Dimethylethanolamine (DMAE) bitartrate
  • Green tea extract
  • Bilberry fruit extract

It is manufactured in an FDA-registered cGMP facility and is one of the safest nootropic supplements on the list containing 100% natural, well-researched, and clinically studied ingredients. One bottle of Neuro Focus + costs $30 and constitutes a month’s supply. However, the price per bottle drops to $20 if you purchase a 3-month supply.



Introduced in 2020, NooBru is a dietary supplement designed to enhance your cognitive health and brain performance. It comes in the form of powder and is marketed to older adults, students, and athletes.

NooBru contains powerful brain-supporting ingredients: phosphatidylserine, CDP choline, n-acetyl l-tyrosine, absorbagen, sulbutiamine, and huperzine A, alpha GPC, l-theanine, ashwagandha, vitamin B6, and vitamin B5. NooBru comes in two versions, i.e., Shield and Advantage. You can mix either one of these powders with a beverage of your choice. One bottle of NooBru is priced at $55.

Hunter Focus


Developed by Roar Ambition, Hunter Focus is a nootropic supplement formulated with all-natural, high-quality ingredients that enhance your cognitive function. The primary elements present in the supplement include:

  • Passionflower
  • Phosphatidylserine
  • Bacopa monnieri

Hunter Focus is marketed as an intelligent solution designed to eliminate brain fog. The supplement is one of the most widely recommended nootropics due to its ingredient transparency. With attractive packaging and four capsules per serving, one bottle of Hunter Focus is priced at $60.



Infused with 13 natural nootropics, BrainPill is a brain-boosting nutritional supplement formulated to enhance your cognitive function. The supplement is marketed as an “unfair advantage” over other nootropic supplements. It claims to support your brain performance by boosting your working memory, eliminating mental fog, promoting mental clarity, increasing cognitive energy, improving your ability to concentrate, and enhancing recall.

Doctors like Dr. Dave David widely recommend BrainPill. Unlike other supplements, BrainPill contains a caffeine-free formula that doesn’t rely on central nervous system (CNS) stimulants to improve mental alertness. It keeps your brain active all day long without giving it high doses of psychoactive substances, e.g., caffeine. It contains scientifically proven ingredients like tyrosine, l-theanine, citicoline, and vitamin B12, among others.

Priced at $69 per bottle, BrainPill is a high-quality cognitive-enhancer containing proper doses of all active ingredients present in it as marketed by its manufacturer.



Infused with bacosides, OptiMind is a nutritional supplement designed to improve your cognitive health, memory, focus, and other aspects. It boosts your mental energy and helps you achieve greater mental clarity. The primary ingredient present in the supplement is bacopa monnieri with 55% bacosides, compounds that help boost serotonin levels.

Due to its bacoside-rich content, OptiMind keeps your mind alert and energetic by boosting serotonin production, regulating serotonin reuptake, and increasing the intensity and duration of its activity at neuronal junctions. The supplement uses clinically studied ingredients that alter the levels of neurotransmitters to boost brain function. The key elements present in OptiMind include l-taurine, phosphatidylserine, synapsa, alpha-lipoic acid, t-tyrosine, and gamma-aminobutyric acid (GABA). One bottle of OptiMind is priced at $29.95 per bottle.

Youthful Brain


Developed by Vitality Now, Youthful Brain is a dietary supplement that helps improve your brain performance by boosting your mental energy, cognition, and overall brain health. It uses a powerful blend of active ingredients like bacopa monnieri, huperzine A, vitamin B12, etc., to improve mental functions such as creativity, memory, attention, and motivation.

Youthful Brain contains virtually the same ingredients as other supplements on the list. However, the elements are present in relatively low doses. One bottle of Youthful Brain is priced at $65, making it one of the most expensive supplements.

Mind & Mood


Developed by UpWellness, Mind & Mood is a nutritional supplement that acts both as a nootropic and mood-enhancer. Unlike most brain health supplements, Mind & Mood helps improve your emotional health while supporting your cognitive health. Replete with adaptogenic ingredients, it calms your nervous system to alleviate anxiety, stress, and episodes of depression.

The supplement contains 5-HTP, gamma-aminobutyric acid (GABA), Rhodiola Rosea extract, l-theanine, and saffron, among many other potent ingredients. The formula is designed by Dr. Amanda Levitt and Dr. Joshua Levitt and is one of the few supplements on the list created by real doctors. One bottle of Mind & Mood is priced at $57.



Developed by PureEssence, BrainEssence is a brain health supplement that helps eliminate memory problems, improves your ability to concentrate, and gives you greater mental clarity. The supplement supports your cognitive health-supporting brain plasticity, i.e., boosts your brain’s ability to change and reorganize due to experience. It also increases your energy and mood.

The primary ingredients present in BrainEssence include bacopa monnieri extract, ashwagandha, Rhodiola Rosea, alpha-lipoic acid, Chinese club moss extract, and acetyl l-carnitine. Priced at $30 per bottle, the supplement comes in the form of tablets rather than capsules.

Elm & Rye Nootropics


A brain health supplement offered by Elm and Rye, Nootropics is formulated to improve your cognitive function, specifically executive functions, i.e., memory, creativity, motivation, etc. It contains phosphatidylserine, gamma-aminobutyric acid, bacopa monnieri extract, alpha GPC, l-tyrosine, l-theanine, and B vitamins as primary ingredients. Infused with a high dose of caffeine, the supplement provides you with long-lasting energy boosts that help increase your productivity. The quantity of caffeine per serving of this supplement is equivalent to 2 to 3 cups of coffee at once.

Memory Hack


Created by Nutrition Hacks, Memory Hack is a dietary supplement that acts as a cognitive enhancer. The supplement is designed to improve the three major processes involved in memory, i.e., encoding, storage, and retrieval. It helps alleviate symptoms of many memory disorders, e.g., dementia, mild cognitive impairment, amnesia, etc.

The ingredients present in Memory Hack include l-theanine, choline, Ginkgo Biloba, and St. John’s worst, among many others. Though Memory Hack helps improve memory retention, in the long run, it doesn’t deliver results overnight. The supplement should not be relied upon for total restoration of memory. It’s a mild nootropic that helps slow down age-related cognitive decline. Priced at $69 per bottle, Memory Hack is backed by a 60-day money-back guarantee.

Cymbiotika Golden Mind


Developed by Cymbiotika, Golden Mind is a brain-enhancing dietary supplement that comes in liquid form. The supplement contains mind-boosting ingredients like lion’s mane, Rhodiola Rosea, l-theanine, Gotu kola extract, sea buckthorn oil, phosphatidylserine, and a blend of 82 ocean minerals.

Golden Mind boosts your brain function by promoting blood circulation in the brain tissue. The supplement is infused with ingredients that stimulate cell production in the brain and nourish the existing brain cells. One bottle of Golden Mind is priced at $50.

Amy Myers MD NeuroLive


NeuroLive is a nootropic nutritional supplement formulated by Amy Myers, MD. The supplement contains high-quality brain-boosting ingredients, e.g., mucuna pruriens seed extract, phosphatidylserine (as Sharp•PS® GREEN), l-theanine, vitamin B6, bacopa monnieri, and Ginkgo Biloba leaf extract.

NeuroLive is replete with antioxidants that protect your brain from damage by free radicals. The supplement is designed to maintain your memory and thinking ability by promoting a healthy balance of neurotransmitters in your brain. It supports your brain function by boosting blood circulation in the brain. It also produces calming effects, thereby helping alleviate stress and anxiety. Priced at $49.97 per bottle, NeuroLive comes with a 90-day money-back guarantee.

ReMind Solution


ReMind or ReMind Solution is an advanced cognitive enhancer designed to improve memory, focus, thinking ability, and overall brain function. Infused with powerful antioxidants, the supplement helps your brain tissue recover from oxidative damage caused by free radicals. It also boosts the flow of blood and oxygen to brain tissue, thereby nourishing brain cells. The key ingredients present in the supplement include:

  • Huperzine A
  • Vinpocetine
  • St. John’s wort
  • N-acetyl l-carnitine
  • Ginkgo Biloba extract
  • L-glutamine
  • Phosphatidylserine

Priced at $69 per bottle, ReMind is one of the most expensive supplements on the list. Though ReMind comes with a premium price tag, it provides few advantages over other nootropics falling in the same price range.

Oweli Neuro


Developed by Oweli, Neuro Brain & Focus is a brain-enhancing supplement that supports your cognitive health and fights age-related cognitive impairment. The supplement claims to unleash 100% of your brain’s potential. It is packed with brain-supporting ingredients like:

  • B vitamins
  • Dimethylethanolamine (DMAE)
  • Inositol
  • Phosphatidylserine
  • Huperzine A
  • Bacopa monnieri extract.

Neuro improves your cognitive health by supporting neuroplasticity, i.e., your brain’s ability to change through growth and reorganization. Neuro claims to deliver life-changing results by enabling your brain to work at 100% capacity. If you find yourself unable to focus on tasks, you can use this nootropic formula to have zen-like focus and multitasking ability. Neuro is very competitively priced and costs approximately $30 per bottle.

ProMind Complex


Created by Carl Henderson, ProMind Complex is a nootropic formula that helps boost your cognitive abilities, i.e., brain-based skills you need to perform simple and complex tasks. Henderson has used his decades of experience to design an effective mind-boosting supplement that boosts your mental ability to reason, plan, comprehend, think, learn, and solve problems.

The primary ingredients present in ProMind Complex include:

  • Huperzine A
  • L-glutamine
  • Phosphatidylserine
  • Vinpocetine
  • Bacopa monnieri extract

Although the supplement is replete with brain-enhancing elements, the dosage for each ingredient is incredibly low. ProMind is one of the most high-priced supplements on the list, with one bottle costing $69.



NeuroGum is the only nootropic supplement on the list that comes in the form of gums. It is a sugar-free energy gum that comes in mint and cinnamon flavors. Neurogum is formulated with powerful nootropics that work in synergy to boost your mental energy, improve your focus, and give you greater mental clarity. Each gum is packed with a potent blend of mind-boosting ingredients, including caffeine, l-theanine, and B vitamins.

NeuroGum uses a patented cold compression system to maximize the bioavailability and absorption of ingredients present in it. NeuroGum comes in two packs: one containing six gums and one containing 12 gums. The former costs $21, and the latter costs $39.

Qualia Mind


Developed by Neurohacker Collective, Qualia Mind is a brain-boosting nutritional supplement that supports your cognitive function and ensures long-term brain health. Neurohacker Collective offers four dietary supplements, i.e., Qualia Mind, Qualia Mind Essentials, Qualia Focus, and Qualia Mind Caffeine.

Qualia Mind is infused with 28 powerful ingredients, i.e., ginkgo Biloba, alpha GPC, bacopa monnieri, Celastrus paniculatus, DHA, etc., that work synergistically to improve your memory, focus, and thinking ability. Priced at $59, Qualia Mind comes with a 100-day money-back guarantee.



Developed by NaturalCell, NeuroActiv6 is a cognitive-enhancement formula that helps boost your brain performance by improving your memory, focus, and attention. The formula comes in powdered form and can be mixed with the beverage of your choice. It promotes healthy brain functioning by preventing oxidative cell damage, promoting neural communication, and increasing blood flow to the brain tissue.

NeuroActiv6 contains a powerful blend of brain-boosting ingredients: B vitamins, citicoline, ashwagandha, turmeric, coffee fruit extract, and grape seed extract. Priced at $46 per bottle, NeuroActiv6 offers a 60-day money-back guarantee.

Synapse XT


A dual-action formula, Synapse XT supports both brain health and hearing ability. Marketed to older adults, Synapse XT is a nutritional supplement that treats all symptoms of age-induced cognitive decline, i.e., forgetfulness, impaired hearing ability, confusion, etc. It contains a powerful blend of vitamins, minerals, plant extracts, and herbs that work in synergy to minimize signs of brain fatigue.

Regular intake of Synapse XT helps improve memory, hearing, and ability to focus in older adults. The supplement is loaded with ingredients that help boost activity on neuronal junctions, thereby supporting communication between brain cells. Synapse XT is one of the most high-priced nootropics on the list, with its single bottle priced at $69.

NooCube Brain Productivity


Developed by neuroscientists, NooCube Brain Productivity uses all-natural ingredients to support your cognition and overall brain health. It is a caffeine-free dietary supplement that helps alleviate the symptoms of all types of cognitive dysfunctions.

The primary ingredients present in the supplement include huperzine A, alpha GPC, bacopa monnieri, and Cat’s Claw extract, all of which are known to support cognitive health. One bottle of NooCube costs $60 and comes with a 2-month money-back guarantee.

Key ingredients in NooCube Brain Productivity include Alpha GPC, Huperzine A, cat’s claw extract, and Bacopa monnieri. Backed by a 60-day money-back guarantee, NooCube’s Brain Productivity formula is priced at around $60 per bottle, delivering good value without compromising quality, ingredients, or dosages.



Developed by Natural Stacks, NeuroFuel is a nootropic supplement that helps eliminate mental fatigue and improves cognitive function. It is the only “open source” supplement on the list as it traced all ingredients and sources on the blockchain. It uses unique ingredients like artichoke extract to improve your brain performance.

Additionally, it contains l-carnitine, vitamin B6, and l-phenylaniline that add to the effects of artichoke leaf extract. The supplement includes minimal ingredients with substantial doses, making it one of the most effective nootropics. NeuroFuel is very competitively priced, with one bottle costing $30.



CogniBiotics is a brain health supplement that contains a powerful blend of natural ingredients that work in synergy to improve your memory and eliminate mental fatigue. It is formulated to address cognitive impairment associated with poor gut health. It targets your brain by optimizing digestion.

Infused with 17 stress-alleviating and brain-boosting herbs, CogniBiotics improves your gut microbiota to boost your cognitive function. The supplement also comes with brain-friendly probiotic strains that help promote healthy bacteria levels in your digestive tract. One bottle of CogniBiotics costs $62.

How We Ranked The Best Nootropic Supplements?

Though all brain health supplements make similar promises, only the best ones live up to their word. After perusing lab reports, clinical studies, research papers, and customer reviews, our editorial team came up with the best nootropic supplements available in the market. Our editorial team took the following factors into account while compiling the list:

Advertised Benefits

In 2019, the U.S. Food and Drug Administration warned the public regarding marketing frauds and advertising scams related to nootropic supplements. Our editorial team was particularly wary of companies that make unrealistic claims about their products. There are no supplements on the list that exaggerate their usefulness by promising to supercharge your brain overnight. We only included products from companies that are honest and transparent in their advertising.

Scientifically-proven Ingredients

We preferred nootropic supplements with scientifically proven ingredients over supplements that contain filler ingredients with no scientific backing. All nootropic supplements on the list contain plant and herbal extracts whose effectiveness in boosting brain health has been supported by scientific evidence. All supplements included in the list contain well-researched, clinically-studied, and scientifically proven ingredients.

Safe & Effective Dosages

All supplements included in our list contain the right ingredients with the dosages. The effectiveness of a nootropic formula depends very much on the number of elements present. At times, too much or too little of an ingredient might render the entire formula ineffective.


Most nootropic supplements available in the market conceal weak dosages and filler ingredients under proprietary blends. In the supplement space, many companies cause you to believe that their product contains unique brain-boosting ingredients – when all you’re getting is 300 milligrams of caffeine hidden within a 350mg proprietary blend. Our editorial team was specifically wary of companies that do not disclose full ingredient labels or hide doses under proprietary blends.

Anecdotal & Empirical Evidence

At times, even the best nootropic supplements fail to yield results. What works for one person may not work for the other. Therefore, we took customer reviews and subjective experiences into account while compiling the list. At times, the supplements that are not backed by ample scientific research turn out to be most effective.

Formula Development

While real doctors formulate some nootropic supplements, some are merely designed by marketers. All supplements included in our list are either developed by doctors or contain formulas designed under the consultation of a medical advisory board.

Clinical Testing

As clinical trials are expensive and require time, most companies do not invest in them. Most of the supplements included in our list are offered by companies that invest in clinical trials and peer-reviewed research. Some companies pay third-party labs to test the effectiveness of their formulas.

The Reputation of the Manufacturer

All products on our list are offered by highly credible manufacturers known for creating high-quality, effective formulas. The age of the company did not merely determine the reputation of the manufacturers.

Price & Value

Though some people might want to spend $100 per month on nootropic supplements, some are looking for inexpensive ways to support their cognitive health. Therefore, our list includes products belonging to different price ranges. However, all products are safe and offer good value regardless of their price.

Refund Policy

While compiling the list, our editorial team preferred products that come with a satisfaction guarantee and refund policy. Most, if not all, supplements on our list come with a money-back guarantee.

Scientific Evidence Related To Nootropic Supplements

A tremendous amount of scientific evidence is available that corroborates the effectiveness of nootropic supplements in supporting cognitive health. Most of the ingredients present in the nootropic supplements on your list are backed by decades of scientific research.

Bacopa monnieri is one of the most well-researched and clinically-tested ingredients present in brain health supplements. It has been used in Chinese folk medicine and Ayurvedic (traditional Indian) medicine for centuries.

According to a study conducted in 2001, bacopa monnieri may enhance higher-order cognitive processes if administered for a prolonged period, e.g., three months. Researchers found that the herbal extract was specifically effective at improving executive function, i.e., memory, creativity, motivation, etc. Another study conducted in 2008 concluded that regular administration of 300mg of bacopa monnieri could help inhibit cognitive impairment in older adults. Today, the efficacy of bacosides, compounds isolated from Bacopa monnieri, is supported by zillions of clinical trials and studies.

Like bacopa monnieri, Ginkgo Biloba has also been used for centuries in traditional Chinese medicine. Both anecdotal evidence and scientific research verify its effectiveness as a cognitive enhancer. In a study conducted in 2001, participants were given a blend of Ginkgo Biloba and vinpocetine regularly for two weeks. After two weeks, researchers observed noticeable cognitive improvements, e.g., improved memory in more than half participants.

Similarly, the mind-boosting and adaptogenic properties of ashwagandha have been corroborated by ample scientific research. The herb contains powerful antioxidants that fight off neurotoxins present in the brain. The mind-protecting compounds present in ashwagandha help impede cognitive decline induced by the process of aging.

Other ingredients present in nootropic supplements that have been extensively studied include huperzine A, l-theanine, Panax ginseng, and caffeine. Huperzine A acts as a cholinesterase inhibitor to boost healthy levels of neurotransmitters in the brain. Some studies suggest that it might help impede the cognitive impairment associated with Alzheimer’s. Similarly, l-theanine and caffeine are extensively studied and tested for their brain-boosting properties. Both ingredients have been proven to support brain function in many ways, i.e., promote gray matter formation, adjust neural pathways, and boost brain electrical activity.

Nootropics Side Effects

The likelihood of side effects is rare in healthy adults if the administration is carried according to the recommended dosage. Nevertheless, some people may experience minor side effects like nausea, headaches, and digestive discomfort. People who do not have any underlying health conditions are unlikely to experience any kind of side effects.

Nootropic supplements containing central nervous system (CNS) stimulants, i.e., caffeine, may cause side effects like anxiety, nausea, chest tightness, and jitters if administered at high doses.

Some people may experience allergic reactions to certain ingredients present in the supplement. For example, bacopa monnieri may cause an allergic reaction in your gastrointestinal tract. Typically, the side effects go away in a few weeks. However, if you experience severe and persistent side effects, you should immediately cease use and consult a doctor.

Frequently Asked Questions About Nootropics

We get zillions of questions regarding nootropics daily. Here are some of the most frequently asked questions about nootropics and the role they play in your brain functioning:

Q: What are nootropics?

A: Nootropics are a class of substances, e.g., drugs and supplements that claim to support your cognitive health and boost your brain performance.

Q: What do nootropics do?

A: Nootropics support your cognitive health and improve your brain performance in a myriad of ways. Some nootropics act as stimulants to keep you mentally alert. Others boost memory and impede age-related cognitive decline.

Q: Where can I take a nootropic?

A: You can buy a nootropic supplement online from Amazon or other major retailers. The recommended dosage for most nootropic supplements is one or two capsules a day with a glass of water. You must call your doctor before taking the supplement.

Q: What does “nootropic” mean?

A: “Nootropic” is a term coined by Dr. Corneliu E. Giurgea, a Roman psychologist in the 1970s. Dr. Giurgea combined three Greek words, i.e., noos (intelligence), vouc (Mind), and trope (turning), to form the word “nootropic,” which roughly translates into mind-turner.

Q: Are nootropics legal?

A: Yes, nootropics are legal in all 50 states of America. It’s legal to buy, possess, and consume nootropic supplements containing ingredients approved by the FDA. Most nootropics are neither controlled nor scheduled by the state.

Q: Are nootropics safe?

A: Nootropics are generally considered safe as most nootropic supplements contain ingredients Generally Recognized As Safe (GRAS) by the FDA. If you follow the recommended dosage instructions, you’re unlikely to experience any side effects or safety issues. Nootropics only become unsafe when not administered according to the instructions, i.e., combined with drugs experimented with dosages, etc. If you have an underlying medical condition, you can affect your health adversely by taking nootropics.

Q: Do nootropics cause side effects?

A: Nootropics are generally safe and do not cause any side effects. However, some people may experience minor side effects, e.g., nausea, headaches, jitters, and digestive issues in rare cases.

Q: What are nootropics used for?

A: Nootropics are used to boost cognition in both young and older adults. They can be administered by both healthy individuals and adults experiencing age-related cognitive decline. Nootropics are most commonly used to treat memory problems.

Q: Who are nootropics marketed to?

A: Nootropics are marketed to older adults, students over 18, athletes, and people looking to have a cognitive edge over their competitors.

Q: Are all nootropic supplements made from natural ingredients?

A: Though most nootropic supplements contain 100% natural ingredients, i.e., vitamins, minerals, herbs, and plant extracts, some may include synthetic compounds. You should check the ingredients label before buying.

Q: Are nootropic supplements vegan?

A: Yes, almost all nootropic formulas that come in powdered or liquid form are vegan. However, supplements that come in the form of capsules contain gelatin made from beef or pork.

Q: Can nootropic supplements cause dependence?

A: Generally, nootropics supplements are not considered addictive. However, some nootropic supplements contain ingredients that have the potential for addiction or dependence.

Q: Do I need a prescription to buy nootropic supplements?

A: When it comes to buying nutritional supplements, you do not need a prescription. You only need a prescription to purchase nootropic drugs, e.g., modafinil (Provigil). However, you must talk to the doctor before taking any nootropic supplement.

Q: Can nootropic supplements help treat Alzheimer’s?

A: Nootropic supplements are not meant to treat cognitive disorders. However, they may help alleviate the symptoms associated with dementia and other types of cognitive dysfunction. For a progressive neurological disease like Alzheimer’s, you should take prescription nootropic drugs instead of nutritional supplements. You must talk to your doctor before taking any nootropic.

Q: When should I take nootropics?

A: Nootropics should be taken in the morning or early afternoon to boost your stamina and productivity during regular working hours. If the supplement you’re taking contains a central nervous system (CNS) stimulant, e.g., caffeine, you should avoid taking it in the evening or late at night to prevent disruptions in your sleeping cycle.

The Top 33 Nootropic Brain Booster Supplements Conclusion

Nootropics have become very popular in the supplement space. From senior citizens to college students, everyone is taking nootropics to enhance their cognitive ability. There are zillions of nootropic supplements available in the market that help boost brain performance and support all aspects of your mental health. Try one of the 33 top nootropic supplements today!

RELATED: Mind Lab Pro Reviews – What are the Customers Saying?

Affiliate Disclosure:

The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.


Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

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