Best Nootropic Supplements [2021] Top Nootropics That Work!

Nootropics, also known as smart drugs, enhance memory, cognition and improve brain health.

Some nootropics are blends of herbal extracts, minerals, and vitamins. At the same time, others increase blood circulation to the brain. Nootropics supplements are in more demand than ever before; therefore, choosing the right supplements from various options available in the market is challenging.

We want to assist you, so we have made a list of the best nootropics supplements available on the market.

The Best 33 Nootropics Supplements In 2021

Out of hundreds of nootropics supplements for improving brain health, we have formulated a list of the most effective and safe supplements. This list is developed based on a variety of essential ranking factors.

  • SANE Vitaae
  • Mind Lab Pro
  • Nuzena Neuro Focus +
  • NooBru
  • Nootrogen
  • Ageless Brain
  • Onnit Alpha Brain
  • Hunter Focus
  • Qualia Mind
  • Performance Lab Mind
  • Vital Plan Brain Boost
  • NaturalCell NeuroActiv6
  • Synapse XT
  • NooCube
  • Natural Stacks NeuroFuel
  • UpWellness Mind & Mood
  • PureEssence BrainEssence
  • PureHealth Research Ageless Brain
  • Brain C-13
  • Cymbiotika Golden Mind
  • Elm & Rye Nootropics
  • CogniBiotics
  • Amy Myers MD NeuroLive
  • Neuro
  • OptiMind
  • Youthful Brain
  • Oweli Neuro
  • ReMind Solution
  • BrainPill
  • ProMind Complex
  • Memory Hack
  • MemoSurge
  • Memo Defend

Let’s get into the details of each nootropic supplement on our list!

SANE Vitaae


SANE Vitaae is one of the top nootropic supplements on this list due to a variety of reasons. Unlike other nootropics, Vitaae contains antioxidants such as CoQ10 to tackle inflammation in the brain. Some of the benefits of SANE Vitaae are enhancing mental clarity, concentration, and mood.

The company claims that the supplement increases brain energy utilization by 13.6% and membrane turnover by 26%. Each serving (3 capsules) of SANE Vitaae contains essential ingredients such as vitamin D, citicoline, acetyl L-carnitine, omega 3 fatty acids, folate, and CoQ10.

Mind Lab Pro


If you are a first-time user of nootropic supplements, Mind Lab Pro is the right choice. This supplement is expensive but includes 11 science-backed ingredients, including citicoline, Lion’s mane mushroom, phosphatidylserine, bacopa monnieri, Rhodiola Rosea N-acetyl-l-tyrosine, and many more elements.

The NutriGenesis vitamins maximize the bioavailability and absorption of other nutrients, thus making the supplement more powerful. Mind Lab Pro is an internet top-rated supplement as it has third-party lab-tested ingredients and neuroscientists in the medical advisory board.

Nuzena Neuro Focus +


Nuzena Neuro Focus + is one of the most cost-effective supplements on this list, as, at only $60, you get three bottles of this supplement. It is a fusion of glutamic acid, green tea extract, bilberry fruit extract, DMAE bitartrate, and other essential ingredients.

The company claims that their nutritional supplement supports memory, focus, and cognitive function of the brain. Moreover, it is GMP certified and made in an FDA approved facility.



NooBru is a transparent supplement that mentions the list of active ingredients and their dosages to the customers. Some of the elements in NooBru include Ashwagandha, alpha GPC, L-theanine, vitamin B5, Huperzine A, and choline bitartrate.

You can consume tasty NooBru powder by mixing it in any beverage of your choice. It has proven advantages in boosting immunity, improving focus, energy, cognition, and mental clarity.



Nootrogen is an affordable formula than other nootropic supplements on our list. It has unique ingredients that you won’t see in other supplements. These ingredients include L-tyrosine, glutamic acid, DMAE, amino acids, niacin, Pantothenic acid, and herbal extracts.

At a budget-friendly price of $30, you can have improved focus, motivation, clarity, cognition, energy, and decreased stress.

Ageless Brain


If you are tired of consuming ineffective nootropic supplements, Ageless Brain is the right pick for you. The Ageless Brain has a beneficial effect on improving cognition due to the essential ingredients added to this formula.

Some of the vital ingredients in Ageless Brain nootropic supplements are Camu, dragon’s blood, bacopa monnieri, guayusa, cat’s claw, and cinnamon. The company claims that this nootropic supplement is best for you if you want a laser-like focus, crystal clear memory, and a sharp mind.

Onnit Alpha Brain


Onnit Alpha Brain, Joe Rogan, the owner, claims that this formula supports focus, memory, and cognition. Unlike most supplements on this list, the Onnit Alpha Brain formula wins the race among competitors, backed by research and clinical trials.

The reasonable formula in terms of cost contains oat straw, cat’s claw, bacopa monnieri, huperzia Serrata, L-tyrosine, and L-theanine.

Hunter Focus


Hunter Focus contains natural and high-quality ingredients for providing clear thinking. It is also famous for its attractive packaging and transparency.

The company discloses all the dosages of ingredients which is a positive point of the supplement. Each serving (four capsules) includes safe and tested Bacopa monnieri, phosphatidylserine, and passionflower, a solution to mental fatigue.

Qualia Mind


Qualia Mind from Neurohacker Collective is a well-known nootropic supplement that contains 28 essential ingredients to improve focus, energy, memory, and brain health. The company offers four nootropic supplements: Qualia Mind Essentials, Qualia Focus, Qualia Mind caffeine-free, and Qualia brand.

One of the advantages of this supplement is that its manufacturing company offers a 100-day money-back guarantee, thus keeping it above the competitors.

Mind By Performance Lab


The Mind nootropic supplement is from one of the best supplement-producing companies, Performance Lab. This effective formula can boost brain energy by 13.6%, support memory and focus, enhance recovery, and improve motivation if taken daily.

Performance Lab Mind contains active ingredients such as L-tyrosine, citicoline, phosphatidylserine, and maritime pine bark extract. Also, the supplement includes antioxidants, minerals, vitamins, and other nutrients for improving cognitive brain function.

Brain Boost


Dr. Bill Raw has created a Brain Boost supplement for improving memory, supporting cognition, mental clarity, focus, immunity, mood, natural energy, and gut microbes.

Brain Boost from Vital Plan contains essential ingredients for enhancing your health and wellness. These ingredients include ginkgo Biloba, bacopa monnieri, cat’s claw, Ashwagandha, and lion’s mane mushroom. The Brain Boost supplement is one of the most potent and transparent formulas as it discloses all relevant information regarding the formula.



If you do not like to consume tablets, then NeuroActiv6 powdered formula is the right choice. You can take this nootropic supplement by mixing one scoop of powder in any beverage of your choice. Neuro Activ6 includes a range of superfoods such as Ashwagandha, turmeric, grape seed extract, citicoline, coffee fruit extract, and vitamin B.

The company claims that it can restore brain energy, prevent oxidative stress, increase BDNF levels, support healthy cortisol levels, and promote neural communications. They also offer zero risk purchases with a 60-days money-back guarantee.

Synapse XT


If you are an aged individual looking for a supplement to improve hearing and cognition, Synapse XT is a good solution for you. It contains plant-based extracts, minerals, herbs, vitamins, and other essential ingredients to support brain function and hearing.

The Synapse XT manufacturing company claims that the formula can support senses and sounds, improve communication between cells, support memory, hearing, and cognitive function.

NooCube Brain Productivity


NooCube Brain Productivity is a nutritional supplement by a neuroscientist. This supplement lacks caffeine but uses plant and herbal extracts to support cognition. Some of the other active ingredients included in the formula are Alpha GPC, Cat’s claw extract, Huperzine A, and bacopa monnieri.

NooCube Brain Productivity supplement is an expensive one in this list but delivers good value, high-quality ingredients in proper dosages to support the brain’s cognitive function.



NeuroFuel by Natural Stacks is the original formula for improving focus, concentration, and improved memory. Unlike other formulas, it contains large doses of a small number of ingredients making it an effective nootropic supplement.

This supplement is powered by blockchain technology and is the only open-source formula on this list. A few ingredients in this supplement are artichoke extract, vitamin B6, acetyl-L-carnitine, and L-phenylaniline. These ingredients have proven action on supporting neurotransmitters in the brain.

Mind And Mood


Mind And Mood is one of the supplements on this list formulated by a team of doctors. Dr. Joshua Levitt and Dr. Amanda Levitt created this formula by adding eight active ingredients such as 5-HTP, GABA, Saffron, L-theanine, passionflower, L-tyrosine, and Rhodiola Rosea.

The company claims that the Mind And Mood formula improves your emotional health and manages stress, fatigue, brain fog, and anxiety.



PureEssence Company discloses all ingredients added in the BrainEssence formula to know what you are consuming. Some ingredients added to this formula are Acetyl-l-carnitine, Gotu Kola Leaf, bacopa monnieri, Ashwagandha, Chinese club moss, schizandra, Rhodiola Rosea, mucuna pruriens, and fisetin stem.

You must take two tablets of BrainEssence daily for optimum benefits such as improving focus, memory, clarity, energy, and mood.

Pure Health Research Ageless Brain


Dr. Holly Lucille created an Ageless Brain nutritional supplement. The formula, reviewed in the AP News here, can decrease brain fog and anxiety, boost memory and cognitive function, and enhance focus. Some ingredients added to the formula are vitamin B, caffeine, GABA, and Huperzine A. However, we don’t know the exact dosages of these ingredients that are a drawback of this supplement.

Moreover, the company offers a one-year money-back guarantee, so you can get a refund if the formula does not suit you.

Brain C-13


Brain C-13 from zenith Labs is one of the top-rated formulas on this list as it is transparent in disclosing the ingredients and their dosages. This supplement contains herbal extracts, herbs, minerals, vitamins, DMAE, rosemary leaf, Rhodiola Rosea, ginkgo leaf, huperzine A, turmeric, and phosphatidylserine.

A medical advisory board with expert doctors formulates Brain C-13, and you must take three capsules per serving or optimum benefits.

Cymbiotika Golden Mind


Cymbiotika Golden Mind is the only supplement available as a liquid tincture instead of powder or capsule. Like other supplements on our list, it contains lion’s mane powder extract, Rhodiola Rosea, L-theanine, and organic phosphatidylserine.

However, there are some unique ingredients that you won’t find in other formulas, such as buckthorn oil, Gotu kola extract, and a blend of 82 minerals. By consuming Golden Mind from Cymbiotika, you can reduce brain fog, nurture brain cell growth, and protect your brain.

Elm And Rye Nootropics


Elm And Rye Nootropics supplement is the highest-priced formula on this list. Surprisingly it contains about 268mg of caffeine which equals about 2 to 3 cups of coffee. Other ingredients that you can get from this nootropic supplement are L-theanine, B vitamins, L-tyrosine, alpha GPC, GABA, bacopa monnieri, and phosphatidylserine.

These ingredients enhance productivity, attention, stamina, memory, concentration, cognitive function, and focus.



CogniBiotics is a nootropic supplement that acts on the digestive system for supporting brain health, mental clarity, memory, learning, and focus. The gut bacteria play an essential role in improving brain performance and cognition.

Therefore CogniBiotics contains 17 nootropic and adaptogenic herbs that improve gut flora and thereby boost cognitive function, mood and decrease stress. Moreover, the supplement also has ten brain-friendly probiotic bacterial strains to support bacteria levels in your gut.

Amy Myers MD NeuroLive


NeuroLive is a doctor’s formulated supplement by Amy Myers MD. It is a brain booster formula containing seven high profile micronutrients such as mucuna pruriens seed extract, bacopa monnieri, whole plant extract, ginkgo Biloba leaf extract, Phosphatidylserine, N-Acetyl Tyrosine, and L-Theanine.

These ingredients, along with vitamin B6, fight against free radicals and oxidative damage. Also, it provides support to the brain cell membrane, supports memory and recall, enhances energy production and ideal methylation, supports blood circulation and healthy vasculature in the body.

With free shipping, third-party lab testing, and 90 days refund policy, this supplement makes its place on our list of best nootropic supplements.

Neuro Gum


Neuro Gum is a functional gum for boosting energy, increasing calmness and focus of your mind. The company sells three different products: Neuro Gum for energy and focus, Neuro Gum for calm and clarity, and Neuro Gum for an ideal state.

The gums and mints are available in cinnamon and peppermint flavors which many consumers like instead of swallowing a bitter capsule. Whether you are searching for an energy booster in the morning or any other time of day, you can take Neuro Gum or mint.



OptiMind is a nootropic supplement containing an active ingredient, Bacopa monnieri, with 55% bacosides. Bacosides are the vital chemicals found within this supplement to enhance its beneficial effects. Consuming OptiMind regularly gives you enhanced cognition, mental clarity, boosted energy, attention, and focus.

OptiMind is priced at $39 for 32 capsules (16 servings). You must consume two pills each day for optimum benefits.

Youthful Brain


The ingredients found in Youthful Brain, mentioned in the AP News here, include bacopa monnieri, vitamin B12, and Huperzine A; however, the dosages are lower than other supplements.

This formula treats age-related memory loss and turbocharges your brain at the cellular level. It nourishes every part of the brain and helps to enjoy clarity and sharpness of the brain.

Oweli Neuro


Oweli Neuro Brain and Focus formula is a unique nootropic complex to enhance cognition, and mental performance, support memory, and learning enhance multitasking abilities, promote mood, fight stress, and promote zen-like focus and flow states.

Some of the key ingredients in Oweli Neuro are bacopa monnieri, huperzine A, DMAE, inositol, phosphatidylserine, and vitamin B. You must take two capsules daily for improved concentration and cognitive function.

ReMind Solution


ReMind Solution is an expensive formula; thus, it gains a lower place on this list. It uses clinically proven ingredients to target anxiety, cognitive problems, stress, lack of focus, and other issues.

The company offers discount offers on multiple bottles and is backed by a 60-days money-back guarantee.

Brain Pill


Brain Pill is marketed as an unfair advantage over the competition. It offers 13 nootropics to target mental fatigue, boost memory and focus, eliminate brain fog, improve cognitive function, and improve learning abilities.

Fortunately, this formula does not contain caffeine, but citicoline, l-theanine, vitamin B12, and tyrosine stimulate consumers’ brainpower. The company claims to use hefty dosages of ingredients; however, little information about the exact doses of ingredients in Brain Pill are disclosed.

ProMind Complex


Carl Henderson created the ProMind Complex formula with his vast years of experience. He claims that this formula is a perfect nootropic supplement. Some of the ingredients added to the ProMind Complex are L-glutamine, bacopa monnieri extract, vinpocetine, phosphatidylserine, and huperzine A. However, the main drawback is that the components are lower doses than those found in other supplements.

Memory Hack


Memory Hack is a supplement created by Nutrition Hacks for cognitive function. It is priced at $69 higher than many other supplements, yet it includes ingredients in small doses.

The company claims that the formula restores memory loss within six months and mainly targets people with memory disorders; however, it is unrealistic.

Moreover, the company provides a 60-days money-back guarantee and bonus offers, so you can get a refund if you don’t like the supplement.



MemoSurge is an innovative supplement that works in three steps. Firstly, it fires up neurotransmitters in the brain. Secondly, it repairs damaged brain cells and eliminates brain shrinkage. At last, the formula treats anxiety and insomnia.

This formula is in the final list because it is not transparent in disclosing detailed ingredients, dosages, and concentrations. However, the company claims that MemoSurge improves general health and wellness.

Memo Defend


Researcher Thomas Taylor made Memo Defend nootropic supplements. The supplement is a 620mg proprietary blend of hawthorn, olive, juniper, hibiscus, green tea, vitamin C, niacin, and garlic bulb. However, detailed information about the dosages is not revealed. The most vital ingredient added in Memo Defend is vitamin B12, found in many other supplements.

How We Rank 33 Best Nootropic Supplements

Due to the increasing demand for nootropic supplements, hundreds of formulas are available in the market, and all claim to provide benefits. Unfortunately, not all supplements are equally effective and safe to use.

It becomes challenging to pick the best nootropic supplement, so we have made a list per the following essential ranking factors:

Scientifically-Proven Ingredients

Some ingredients have scientifically proven benefits of improving cognition and brain function as per research and clinical trials. After extensive research, it is established that plant and herbal extracts, minerals, and vitamins can boost brain function.

Optimum Dosages

A nootropic supplement can only be effective if it contains the effective dose of each ingredient. Many companies add science-proven ingredients to their product but not in optimum quantities. We choose those supplements that have the standard dosages of each component, as it increases the efficiency and safety of that product.

Company Transparency And Reputation

Some manufacturers have a long-standing record of producing high-quality and efficient formulas. At the same time, other companies are new in the market and do not disclose transparent labels.

We include those companies that are transparent in disclosing ingredients, dosages, benefits, and side effects of nootropic supplements. Also, companies with a good record of producing clinically effective supplements are on our list of best nootropic supplements.

Doctor Formulated Products

Doctors or the medical advisory board verifies not all supplements. The nootropic supplements that a doctor or nutritionist formulates are best. However, the companies that invest in their medical advisory board and include doctors are included in our list as it increases the credibility of the products.

Lab Testing And Clinical Trials

Most nootropic supplement-producing companies do not test their products in the lab, while some have reliable lab test reports. We prefer those supplements that are verified in the lab or clinically tested for efficiency and safety.

Price Of Products

We have listed the product from lower to higher price range. Whether you have to spend less or more, you will get the nootropic supplement in your price range. We consider those products as our top priority, which offers a good value of money.

Money-Back Guarantee

We rank the nootropic supplement-producing companies that offer a money-back guarantee. The effects of supplements may vary from individual to individual. Therefore, a money-back policy is beneficial for consumers and builds their trust.

Honest Advertised Benefits

Many manufacturers make big claims and market their products with unrealistic benefits. In contrast, other companies advertise actual benefits. We rank the nootropic supplements companies that are transparent and advertise what they offer.

These were some of the ranking factors that we used for making our list of best nootropic supplements in 2021.

Benefits Of Nootropic Supplements – According To Scientific Evidences

Every nootropic supplement producing company makes many claims about the benefits of these supplements. However, do nootropic supplements work? Are there any scientific shreds of evidence supporting nootropic supplements?

Nootropic supplements have gained popularity in the recent past. At present, you can find research and studies supporting the benefits of various ingredients added in nootropic supplements.

Bacopa Monnieri, found in many nootropic supplements on our list, is one of the most studied ingredients. In a 2008 research, researchers found that the cognitive performance of older elders was increased by consuming 300mg of bacopa monnieri. Also, it reduced reaction time and improved memory in these adults. Many researchers concluded that bacosides in Bacopa monnieri are linked to its beneficial effects, such as improving memory and learning.

Another ingredient Ginkgo Biloba is a well-known herb found in many nootropic supplements. It was used as a traditional medicine decades ago and is backed by multiple scientific studies. A 2001 study concluded that when researchers gave ginkgo Biloba and vinpocetine to participants for 14 days, it improved response times and memory.

Moreover, Ashwagandha, used as traditional Indian medicine for centuries, is added in many nootropic medicines. It has been used for sleep, relaxation, stress management, and optimizing cardiovascular health. Research states that ashwagandha targets neurotoxins in the brain that obstruct cognition and memory. A study in 2016 concluded that Ashwagandha has nootropic and mind-protecting effects.

Many of the above best nootropic supplements also contain Huperzine A. In a study in 1999 in china, researchers gave participants Huperzine A, and significant improvements were seen in memory, cognitive function, and symptoms of Alzheimer’s disease.

L-theanine, another popular ingredient found in nootropic supplements, enhances the beneficial effects of caffeine while nullifying its adverse effects. A study concluded that consuming 50mg of L-theanine increased alpha brain wave activity. Similar research stated that L-theanine complemented the effects of caffeine while negating unwanted side effects such as anxiety.

Additionally, clinical trials prove the efficiency of Onnit Alpha Brain nootropic supplement. In a study in 2016, researchers gave Onnit alpha brain supplement to 63 participants of 18 to 35 years of age for six weeks. These participants had improved verbal memory more than the placebo group. Some nootropics also use ginseng to enhance cognition. A study concluded that consuming 200 mg to 400mg ginseng enhances brain performance.

Caffeine is the most popular nootropic agent, and many people consume caffeine regularly for nootropic effects. In a 2021 study, researchers found that caffeine, the world’s most widely consumed nootropic ingredient, alters the grey matter of the brain and brain electrical activity.

Nootropic Supplement Dosages

The dosages of nootropic supplements depend upon the ingredients and their concentration added in each nootropic supplement.

Most nootropics available in tablets or capsules are taken once or twice daily. On the other hand, if the nootropic supplement is available in powder, one scoop of powder mixed with any beverage is consumed regularly for optimum effects.

You must read the label of the supplement packaging for dosage instructions. However, some companies use proprietary labels, so you must consult your doctor before consuming any supplement.

Nootropic Supplement Side Effects

When taken in standard dosages, most people consuming nootropic supplements do not face any side effects; however, you can experience mild discomfort, nausea, indigestion, or headache.

We recommend you follow the dosage instructions on the packaging of the nootropic supplement. If you are already on any medication or suffering from a comorbid condition, consult your physician before starting any supplement.

Nootropic formula contains plant-based ingredients or herbal extracts which are safe to use. Some nootropics contain caffeine that may cause anxiety, jitters, nausea, and chest tightness at large doses.

Frequently Asked Questions About Nootropic Supplements

Q. What is a nootropic supplement?

A: Any supplement that contains ingredients used to boost cognitive function is called a nootropic supplement.

Q. What does a nootropic supplement do?

A: Nootropics support brain performance in different ways. Some supplements boost memory and cognition, while others act on the electrical activity of the brain. Some also increase energy levels by working as a stimulant.

Q. How can I take nootropics?

A: Nootropic supplements are available more easily today than ever before. Nootropic supplements available in capsule and tablet form are taken once and twice per day, while you must consume one scoop of nootropic powder daily by mixing it with any beverage of your choice.

Q. Which one is the best nootropic supplement available today?

A: Any of the top-rated nootropic supplements on our list is the best to use in 2021.

Q. Are nootropic supplements safe to consume?

A: Many nootropics contain ingredients that are generally recognized as safe (GRAS) by the FDA. We recommend you follow the dosage instructions on the packaging of the nootropic supplement. If you are already consuming any medication or are suffering from a comorbid condition, you must consult your physician before starting any supplement.

Q. What are the side effects of nootropic supplements?

A: Most people consuming nootropic supplements do not face any side effects; however, you can experience mild discomfort, jitters, nausea, indigestion, or headache.

Q. What benefits does a nootropic supplement offer?

A: Some of the benefits of nootropic supplements are boosted memory, cognition, and brainpower. It also decreases stress levels and improves energy levels.

Q. Who can benefit from a nootropic supplement?

A: Athletes, college students, entrepreneurs’ parents, and whosoever need a cognitive boost can benefit from a nootropic supplement.

Q. Are nootropic supplements legal to use?

A: Most nootropic supplements contain ingredients that are generally recognized as safe by FDA. These are legal in many states.

Q. Does a nootropic supplement contain natural ingredients?

A: Most nootropic supplements contain natural ingredients such as herbal extracts, plant-based ingredients, vitamins, and minerals.

Q. Does nootropic supplements cause addiction?

A: Most nootropic supplements do not contain an additive ingredient. However, you can get addicted to anything.

Q. When should I take a nootropic supplement?

A: Most nootropic supplements contain stimulants, so it is better to take these supplements in the morning or early afternoon.

The Best 33 Nootropics Supplements In 2021 Final Thoughts

Nootropic supplements are more popular than ever before. You can buy nootropic formulas at major online and offline retailers.

There are varieties of nootropic supplements available today, but not all are equally effective and safe to use; therefore, we have made a list of the 33 best nootropic supplements that you can buy to optimize cognition, memory, and brain performance.

This list is not an alternative to physician advice or an expert doctor. We recommend you consult a health professional to choose the best nootropic supplement for yourself. Always select the supplement that gives you more benefits with minimum side effects.

RELATED: Mind Lab Pro Reviews – What are Customers Really Saying?

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Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.