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Best Immune System Supplements: Top Immunity Boosters 2021

Your body has its built-in defense against disease, sickness, and ailments – the immune system. Health is impossible to achieve with a weak immune system. Sleep, age, diet, exercise all contribute to your ability to stay healthy and happy. Supplements are another way to help strengthen the immunity levels you carry with you every day.

Those of us born with strong immune systems are lucky. Some people must improve their ability to stay healthy with external measures. Healthy habits help improve your immunity levels, so your body can ward off disease or illness.

Supplements are everywhere, with new ones constantly released to the market with the promise of keeping you healthy. Some of these supplements are proven to help strengthen your immunity; others are simply hype. Certain natural compounds derived from plants, including vitamin C, Zinc, and plant derivatives, help improve your body’s natural defense system.

Go to your local store or nutrition shop, and you are guaranteed to see dozens of supplements claiming to support your immune system or boost it to the point of perfect health. Unfortunately, not all supplements are created equal. Most offer little to no benefit, proving instead to waste your time and your money.

This guide is a comprehensive list of the best immune system supplements on the market available in 2021. Our research and the editorial team spent countless hours of research to compile this list of immunity boosters; hopefully, it will shed some light on which to use for your specific needs and which to stay away from.

Below listed immune boosters ranked after carefully considering various pieces of information. Manufacturer specs, web reports, scientific studies, and hard work were used as a factor to determine the following list of boosters.

Best Immune System Support Boosters In 2021

Mushroom Defense

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Main Components- Maitake, White ButtonCordyceps Sinensis, Turkey Tail, Chaga, Royal Sun Agaricus, Reishi, Shiitake, Lion’s Mane, and Black Fungus.


  • Immune cells and mental health stimulation.
  • Better rapid defense response.
  • Increase body’s energy level and T cells.
  • Enhance immune function naturally with powerful antioxidants.
  • Deal with aging signs.

Quantity To Be Taken- Talk to a healthcare professional.

Assurance- 67 days money-back guarantee.

Price- $59.99.

Everybody knows mushrooms are good for you. Some are naturally better than others, containing high-quality extracts or concentrated doses of rare mushrooms. Mushroom Defense is one such supplement containing trace ingredients to help improve memory, cognitive function, mental and physical fatigue, plus much more. This specific supplement is also said to help with infection, both viral and bacterial. Not only that but aspects of physical and mental fatigue are improved using Mushroom Defense. It is made up of purely all-natural ingredients, including a hard-to-find mushroom sourced in Brazil, near Sao Paulo.

For those of you who appreciate all-natural ingredients rather than synthesized ones or have a general belief in the holistic healing power of fungus, Mushroom Defense is the one that ranks top among the best immunity boosters.

Check Official Website.

VitaPost Immune Support

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Main Components- Quercetin, Green Tea, Olive leaf Extract, Vitamin E, Beta-Glucans, Vitamin C, and Arabinogalactan.


  • Better hair growth and skincare.
  • Boost your immune health and energy levels.
  • Antioxidant and powerful anti-inflammatory qualities.
  • Increase white blood cells count.
  • Fight viral and bacterial infections.

Quantity To Be Taken- Two capsules once a day with or without food.

Assurance- No Guarantee.

Price $13.95.

This all-natural supplement for boosting the immune system is primarily made up of botanical extracts for healing your body. Your immune system is in constant barrage by free radicals, toxins, and other unwanted substances. The natural herbs, minerals, vitamins, and extracts that make up VitaPost help strengthen your immune system while supporting its longevity.

VitaPost is one of the most affordable and best immune support supplements out there. Made up of ancient ingredients and modern ones, VitaPost Immune Support works to directly affect your immune system and help it by eliminating free radicals from your body. Each of the components is proven to help the immune system stay healthy.

Check Official Website.

VitaPost Immune Complex

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Main Components-Turmeric, Zinc, L-Glutamine, Vitamin C, Vitamin E, Vitamin B6, and Elderberry fruit extract.


  • Strengthen white blood cells to fight infection.
  • Relieve pain and body aches.
  • Enhanced immune response.
  • Improve brain functioning and give clarity in thinking.
  • Avoid depression, zinc deficiency, and chronic illness.
  • Improve heart and gut health.

Quantity To Be Taken- Two capsules a day with water. Take it 20-30 minutes before you sleep.

Assurance- No Guarantee.

Price $17.95.

Another of the supplements from VitaPost is their Immune Complex. Like the previously mentioned supplement by VitaPost, the complex contains all-natural, proven ingredients. The ingredients list is a little different than those above. Probiotics is one of the staple ingredients – combined with echinacea, elderberry, and some other holistic ingredients. It is more for improving digestion or warding off an oncoming cold, from what I can tell. There is scientific evidence that Vitamin C improves overall immune systems.

If you did not know, the digestive tract is an essential part of your immune system. Healthy bacteria that reside in your gut are vital to healthy immune support. VitaPost Immune Complex supporting gut health to help your gut bacteria flourish significantly & cost-effectively.

Check Official Website.

Simple Promise’s Epishield Plus

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Main Components-Epicor, Vitamin C, Vitamin D, Chaga Mushroom, and Shiitake mushroom.


  • Help at curing a common cold and flu.
  • Improve digestive health and boost immune system function.
  • Fight old age signs and weak memory.
  • Lower cholesterol and blood sugar.
  • Fight inflammation and viral infections.

Quantity To Be Taken- One capsule twice a day.

Assurance-365 days money-back guarantee.

Price- $49.

Here is another dietary supplement that claims to work fast. Within two hours, this immune booster claims to start taking effect on your health. That is a bold statement; considering it is about $50 a bottle, it better work as Simple Promise’s Promise for that price. Ingredients in the pricey supplement are like others we see on this list. The difference, they claim, is that the ingredients used are of higher quality. One ingredient found in Epishield Plus, not seen in each of the previously listed supplements, is fermented yeast. Epicor Fermented Yeast, as it is called, comes from Saccharomyces Cerevisiae. The ingredient makes Epishield Plus unique amongst other supplements. The rumor is that fermented yeast found in this supplement helps to boost your immune system better than any other ingredient.

That does not mean yeast is the only ingredient found in the immune booster. It is a tricky supplement to purchase from the company website. For the most part, it is often sold out.

Check Official Website.

Zenith Labs Nano C

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Main Components- Vitamin C, Natural Orange Flavor, and Water.


  • Boost immune cells and wound healing properties.
  • Manage high blood pressure.
  • Maintain blood uric acid levels to avoid arthritis.
  • Improve memory and thinking with growing age.
  • Avoid common cold and viral infections.

Quantity To Be Taken- One dropper every morning for 30 days.

Assurance- 180 days money-back guarantee.

Price- $49.

One of the best Vitamin C Supplements, created by board-certified physician Dr. Shelton, is claimed to be readily bioavailable because of the liquid form. Many vitamins and minerals people take pass through the system before people properly absorb them into their bodies. Sometimes it is because of malnutrition or possibly not eating with it. Whatever the reason is for most supplements not absorbing correctly, Zenith Labs Nano C is said to avert that problem. Vitamin C is one of the most important substances known to man for supporting a healthy immune system.

Vitamin C helps you recover faster from bacterial and viral infections. Your body absorbs other nutrients better because of Vitamin C. Zenith Labs promises to work so well because it is over a thousand times smaller than traditionally found sources of Vitamin C, hence the name nano.

Check Official Website.

Advanced Bionutritionals Resistol

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Main Components- Platycodon, Eleuthero, Andrographis, Licorice Prickly, and Chaff Flower.


  • Support immunity and healthy respiration.
  • Boost gut health and lymphatic system.
  • Make lung functioning smooth.
  • Avoid catching a common cold and viral infection.
  • Deal with poor brain health and depression.

Quantity To Be Taken- Two capsules a day.

Assurance- Money back Guarantee of 90 days.

Price $29.95.

A simple, holistic botanical containing immune support supplement, Resistol goes in a different direction than the other regular supplements on this list. Rather than pump you full of everyday nutrients, like Vitamin C, Vitamin D, and the like, Resistol uses not commonly found plant extracts and herbs to help you get healthy.

The five-herb-containing supplement comprises Andrographis, Platycodon, Eleuthero, and more, which helps fight upper respiratory tract infections. They call the ingredients in Resistol, Bionutritionals, something not found in any other supplements on this list. If something different is your thing with scientific evidence, you can pick up a bottle.

Check Official Website.

Organixx 7M

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Main Components-Shiitake, Chaga, Maitake, Lion’s Mane, Cordyceps, Reishi, and Turkey Tail.


  • Reduce high cholesterol levels.
  • Fight with skin and hair fall problems.
  • Protect from cough, cold, and common respiratory disorders.
  • Relief from overworking joint pain.
  • Support a healthy immune system.

Quantity To Be Taken- Two capsules in a day for consecutive 30 days.

Assurance- Money back guarantee of 365 days.

Price- $55.

Mushrooms have long been used to boost immunity in the healthy and the ill. Here we have another supplement for mushroom fans. Organixx contains several different mushroom-derived extracts, powders, and other less commonly found mushroom types in Organixx 7M: Lion’s Mane, Turkey Tail, and Cordyceps.

Mushrooms do more than boost the immune system; they also help reduce inflammation in the body. Inflammation is now linked to many different ailments and chronic illnesses. Beta-Glucans give you anti-inflammatory effects, as well as help detox your body. The mushrooms in the supplement are also proven to support the immune system. To benefit from Organixx, you must take the supplement daily. It will help with the immune system, digestion, as well as other symptoms.

Check Official Website.

Bioshield MD

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Main Components- Cocoa Extract, Curcumin Extract, Tart Cherry Extract, Boswellia Serrata, and Resveratrol.


  • Detoxify the body and promote a healthy immune system.
  • Manage blood sugar and pressure.
  • Give better mental health and clarity.
  • Reverse aging signs.
  • Lower the body aches and pain.

Quantity To Be Taken- Once or Two times a day with or without food.

Assurance- Money back guarantee of 365 days.

Price- $49.95.

Here we have another supplement created by an MD, Dr. Mark Rosenberg designed Bioshield MD while working for Sun Coast Sciences. His principal concern was the bioavailability of the supplement. Secondly, he considered exact dosages when making it as well. Bioshield MD is more than a simple immune booster; however, energy, mental, joint, and digestive health will benefit when taking it.

Unlike other supplements on the list, you know you are getting the right amount of each ingredient. There are no fillers or proprietary blends found in other supplements. Some of the elements in Bioshield MD include Cherry, Cocoa, and Green Tea Extract. Others include resveratrol, quercetin and more. Along with helping your health in various ways previously mentioned, the supplement will also help remove free radicals from your body.

Check Official Website.

Vitapost Turmeric & Ginger

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Main Components- Ginger extract, peppercorn extract, and Organic Turmeric.


  • Fight with allergies and morning sickness.
  • Protection from upper respiratory infections.
  • Boost immune health and brain functioning.
  • Avoid catching chronic stress and diseases.
  • Provide robust joint health.

Quantity To Be Taken- One capsule twice a day before meal.

Assurance- No Guarantee.

Price $23.95.

VitaPost Turmeric & Ginger have long been used as anti-inflammatory agents, as well as for beneficial digestion. This supplement is for generalized health, immunity support includes. With the right amount of BioPerine, your body’s immune system will flourish, as will its ability to remove toxins and free radicals.

The high concentration of Turmeric & Ginger found in the supplement is ideal for healing properties. Black pepper and the curcuminoids above are included to help your body process everything efficiently and relieve upper respiratory tract infections.

Check Official Website.

JayLab Pro’s Immuno Defense 4X

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Main Components-Quercetin, Vitamin D, Whole Food Fermentate, and Bromelain.


  • Improve the number of antibodies and T cells.
  • Fight respiratory infections and foreign invaders.
  • Antibacterial and antiviral properties.
  • Get rid of immune-related diseases and promote better immune health.
  • Helpful for absorbing nutrients from your diet.

Quantity To Be Taken- Two capsules one time a day for consecutive 30 days.

Assurance-Money-back guarantee of 60 days.

Price $44.95.

Another simple immune booster, scientifically designed to include just enough of each ingredient, JayLab Pro has created a supplement with only four ingredients. Sometimes, less is more, and that is the case with the simple design in this booster. With only four ingredients formulated adequately in the right amount, your body can quickly assimilate each ingredient for maximum effectiveness. The four ingredients found in the immune support supplement are Vitamin D3, Bromelain, Quercetin, and EpiCor. It is one of two ingredients on the list to contain fermented, dried yeast, AKA EpiCor. The adequate vitamin D levels in Immuno Defence 4X maintain the calcium and phosphate levels in the body.

Check Official Website.

Doctor G’s Q-Ion Immune Defense

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Main Components- Bromelain, Zinc, Camellia Sinensis Extract, and Quercetin.


  • Ensure a healthy inflammation response.
  • Boost overall immune system function.
  • Detoxify and boost your body.
  • Fight against immune invaders and viruses.
  • Reduce body pain and aches.

Quantity To Be Taken- One capsule a day for consecutive 30 days.

Assurance- 60 days money-back guarantee.

Price- $79.95.

Bold statements are made by Doctor G’s Q-Ion Immune Defense Supplement. Claiming the booster helps the body defend itself against viruses and other pathogens is unique on this list. Also, claiming it is Dr approved. It is not seen anywhere else on this list. Whether or not these claims are fact is yet to be proven as far as we can tell. The claims are made in correspondence to the anti-inflammatory properties the supplement has.

Created by Dr. John Gordon, including commonly found ingredients like zinc and bromelain, it seems at first glance to be just like many other immune support boosters on the list. Readily bioavailable, Q-Ion may sound expensive, but a bottle may revive and mend immune response. It is a wise zinc supplement that exists in the market.

Check Official Website.

Immunity 911

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Main Components- Himalayan Raspberry, Graviola Leaf, Mushroom Blend, Himalayan Pomegranate, and Olive Leaf.


  • Fight harmful viruses and foreign invaders.
  • Stimulate the growth of healthy immune cells.
  • Lower the chance of catching bacterial and infectious diseases.
  • Enhance powerful antioxidants and antibodies.
  • Improve your health conditions.

Quantity To Be Taken- Two capsules a day with water.

Assurance- Money back guarantee of 90 days.

Price- $69.99.

The issue with the supplement is the amount of each ingredient on the list. Immunity 911 contains more components than any other on the list; it is also one of the most expensive. Elements used in PhytAge are in relatively low doses, likely making them ineffective at treating anything or helping with immunity-boosting power.

Many health nutritionists speculate the ineffectiveness of the low doses of ingredients like Green Tea leaf extract and Raspberry extracts. There is also no description of manufacturing standards, or ingredient sources, making it hard to trust Phytage. Still, if you would like to try out the immunity support supplement, buying Immunity 911 might be a piece of sound medical advice.

Check Official Website.

Immunity Formulas Immune Support

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Main Components- Peppermint, Turmeric, Cinnamon, Lemon, Bioperine, and Oregano.


  • Provide antiviral and antimicrobial effects.
  • Purify your room’s air.
  • Boost antioxidants and brain activities.
  • Lead you to a robust immune system.
  • Improve your energy levels.

Quantity To Be Taken-You can Apply topically, diffuse, or disinfect to inhale.

Assurance- No Guarantee.

Price- $64.99.

Last on the list; we have a holistically approached immune-boosting supplement. Immunity Formulas, therapeutically designed booster claims to fight pathogens of every type. It operates by boosting your body’s defense-building abilities, usage as a sanitizer, and lastly to purify the air you breathe in. To gain maximum effectiveness, you must take it daily for a period.

Ingredients are herbal, commonly used for hundreds of years. They include substances like Turmeric, Oregano, and Peppermint, each of which has been used to ward off parasites, diseases, and viruses by cultures worldwide. One note, peppermint can be hard on the digestive system, so make sure to test it before long-term usage. You can pick up a bottle of the Immunity Formulas Immune Support, which is relatively expensive compared to other supplements on the list but best to get virus-free surroundings.

Check Official Website.

Immunity Booster Ranking Standards

To compile the list, we considered many factors with our medical expertise. First, we looked at the list of ingredients on each and where they are backed by scientific research. We gave the supplement points if the ingredients listed were proven to improve the immune system, like Zinc. Following good practices and quality control, we also took into consideration where ingredients were sourced.

If there was no way to determine the quality or authenticity of the ingredients, we gave the supplement a lower ranking. Also, regarding quality- control, we checked on where each product was manufactured, and what standards they were held to.


Products manufactured in FDA-approved facilities, under Dr supervision, were naturally bumped up on the ranking chart. We dumped supplements without approved manufacturing standards or those not divulging information.

The effectiveness of ingredients in each product was looked at carefully, as were the dosages used. Any companies making unproven claims or essentially selling snake oils were not given the same respect as those that did, lowering them on the list.


Many supplements we looked at were removed outright from the list, as some made claims they could even prevent illnesses like Covid. There is no supporting evidence, any immune system support supplement can or does treat viruses like Covid-19. Many supplements making claims of this nature were made in countries with little to no regulations, so we did not include them on the list.

Essentially, that means medical professionals legitimately support them.

Companies who made the supplements on the list, who we supported, and you can tell by how we reviewed them, have a long history of creating health supplements that work. We predominantly only ranked companies with a proven track record and no bad reviews from a medical standpoint. Lastly, we ranked the supplements on the list by price and value. If the price was equivalent to usage value and effectiveness, we gave it a spot on the list.

Side Effects of Immunity Boosters

Many ingredients found in these supplements are proven to have health benefits for the immune system. Vegetables, fruits, herbs, minerals, and nutrients can all have positive benefits to your immune function. Taking supplements alone is typically not enough; however, a healthy lifestyle and diet are also required for a boosted immune system.

Just the same, poor diet and lifestyle will naturally weaken your body’s natural immunity to viruses and pathogens. You must take all of this into consideration when thinking of your overall health. A doctor will be able to provide you with the most honest advice, following a physical to determine your personal health needs.

Now let us touch on ingredients found in immunity boosters. Some are long proven, Vitamin C, D, Amino Acid Containing Proteins, Zinc, Probiotics, Elderberry, Echinacea, and Turmeric each are proven to boost immunity to unwanted agents from affecting your system. You can get most of these ingredients from a healthy diet, including poultry, red meat, fish, and other superfoods like berries and various veggies.

To fully support your immune system, you must include various foods into your diet combined with supplements. Garlic and ginger are proven to boost the immune system. Vitamin C is found in most citrus fruits, Oranges, and Grapefruit. Amino acids in the previously mentioned proteins, as well as many different nuts.

Other needed immune boosters like turmeric, and Echinacea are easier to find in supplements and not common in many household fridges or pantries. The key to choosing one out of the many best immunity boosters is research, understanding your body, and ensuring the foods you eat are high-quality.

Important Information on the Immune System

Your immune system lies in your body. Its primary function is to stop unwanted agents from entering your body. Your immune system is responsible for everything from tears, and sneezing, both the body’s first line of defense against pathogens, to producing antibodies that fight off infections. The immune system creates T-cells; they call into play antibodies to help fight infection or directly attack pathogens on their own.

The best vitamins you can take for immunity-boosting properties are Vitamins C, D, and E. Each of these vitamins is readily available from food, the sun, and supplements. They help your body’s innate ability to ward off disease and infection. Different organs also support the immune system, recognizing pathogens as they enter your body. It is therefore essential to keep your internal organs healthy. You can help your immune-oriented organs like the spleen and thymus by eating healthy fruits and greens.

Other factors proven to improve immune functionality include your weight, sleep habits, drug and alcohol use, and activity levels. Toxic substances are guaranteed to lower your immune system, as is heavy drug & alcohol use. Not sleeping weakens your immune system, as does lethargy. These are all factors that promote healthy immune response.

Basically, to stay healthy, eat healthy, sleep well, stay active, and take the right supplements. It all sounds simple but is not easy in the busy world we live in. Hopefully, this guide will help you keep a healthy immune system and thereby a higher quality of life.

FAQs About Immune Support Supplements.

Q. How Does Immunity Work To Keep Us Healthy?

A. The human immune system comprises white blood cells, antibodies, bone marrow, the lymphatic system, spleen, and thymus. Each of these elements is responsible for fighting antigens. When our body encounters foreign invaders, the immune system recognizes them and fights back to protect or minimize the harm. The B lymphocytes generate antibodies or immunoglobulins, which lock onto invaders.

Q. Which Vitamins Are Responsible For Healthy Immune System?

A. Vitamin E, Vitamin C, Vitamin A, and Vitamin D are essential vitamins to support immune function. Apart from that, minerals like Zinc, folic acid, iron, and selenium play a crucial role in mending poor immune function. Above listed immune supplements include these vitamins and minerals that benefit your immunity in many ways.

Q. What To Eat For Healthy Immune Function?

A. You must add the following food in your diet to get a healthy lifestyle- Citrus fruits, Spinach, dark chocolate, berries, Turmeric, ginger, garlic, almonds, elderberry, Oily fish, sweet potatoes, and Fermented Foods.

Q. What Are The Best Options To Get Better Immune Health?

A. Embrace a healthy lifestyle and diet. Eating unhealthy food may result in an increased risk of sickness and diseases. Follow healthy weight tend, stop smoking and consuming alcohol, and avoid unhealthy sleeping habits. Exercising regularly is also a great way to live a healthy and happy life.

Q. Is It Possible to Boost Your Immune System With Immune-Boosting Supplements?

A. No doubt that supplements offer people certain medicinal and health benefits. It is seen people feel energetic and active after consuming immunity system boosters. The elements in power boosters are indeed scientifically verified to offer medical and health benefits.

However, according to FDA regulations, supplements are not claimed to cure diseases or treat infections. We know that drug administration doesn’t regulate the quality of immunity boosters. It would help if you got a supplement only from a licensed healthcare provider.

Final Thoughts About Immunity Boosters:

Immunity supporting boosters majorly consist of vitamins, minerals, fruit, and herbal extracts, which are highly beneficial to enhance innate immunity. We hope that this has helped you choose a Bottle of supplement from the list of the best immunity boosters and feel the difference. You may help your body fight foreign invaders by taking the proper immunization supplement.

RELATED:Best Mushroom Supplements (Review, Compare & Buy Products)

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Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

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